Protein Arginine Methyltransferase 2 (PRMT2) Peptide
PRMT2
Reactivity: Mammalian
Host: Synthetic
BP, WB, IHC
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- Target See all PRMT2 products
- PRMT2 (Protein Arginine Methyltransferase 2 (PRMT2))
- Peptide Type
- Synthetic
- Origin
- Mammalian
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- ESQGEEPAEC SEAGLLQEGV QPEEFVAIAD YAATDETQLS FLRGEKILIL
- Characteristics
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A synthetic peptide for use as a blocking control in assays to test for specificity of PRMT2 antibody,
Alternative Names: PRMT2 control peptide, PRMT2 antibody Blocking Peptide, Anti-PRMT2 Blocking Peptide, Protein Arginine Methyltransferase 2 Blocking Peptide, PRMT2, PRMT-2, PRMT 2, PRMT-2 Blocking Peptide, PRMT 2 Blocking Peptide
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- Application Notes
- Optimal conditions should be determined by the investigator
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
- Buffer
- PBS
- Handling Advice
- Avoid repeated freeze/thaw cycles.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C long term.
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- Target
- PRMT2 (Protein Arginine Methyltransferase 2 (PRMT2))
- Synonyms
- PRMT2 Peptide, DKFZp459N1919 Peptide, HRMT1L1 Peptide, Hrmt1l1 Peptide, AI504737 Peptide, protein arginine methyltransferase 2 Peptide, protein arginine methyltransferase 2 L homeolog Peptide, protein arginine N-methyltransferase 2 Peptide, PRMT2 Peptide, Prmt2 Peptide, prmt2.L Peptide
- Background
- The protein arginine methyltransferases (PRMTs) include a family of proteins with related putative methyltransferase domains that modify chromatin and regulate cellular transcription. PRMT2 inhibits NF-kappaB-dependent transcription and promotes apoptosis and it exerts this effect by blocking nuclear export of IkappaB-alpha through a leptomycin-sensitive pathway, increasing nuclear IkappaB-alpha and decreasing NF-kappaB DNA binding. PRMT2 also rendered cells susceptible to apoptosis by cytokines or cytotoxic drugs, likely due to its effects on NF-kappaB.
- Molecular Weight
- 48 kDa
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