Activin Receptor Type I (ACRV1) Peptide
ACRV1
Reactivity: Human
Host: Synthetic
BP, WB, IHC
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- Target See all ACVR1 (ACRV1) products
- ACVR1 (ACRV1) (Activin Receptor Type I (ACRV1))
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-ACVR1 antibody (Catalog #: ARP45040_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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Activin Receptor Type I (ACRV1) peptide
ACRV1 Reactivity: Human, Dog, Mouse, Rat Host: Synthetic BP, Imm
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- ACVR1 (ACRV1) (Activin Receptor Type I (ACRV1))
- Synonyms
- ACTRI Peptide, ACVR1A Peptide, ACVRLK2 Peptide, ALK2 Peptide, FOP Peptide, SKR1 Peptide, TSRI Peptide, ActR-IA Peptide, ActR-I Peptide, ActRIA Peptide, Acvr Peptide, Acvrlk2 Peptide, Alk-2 Peptide, Alk8 Peptide, D330013D15Rik Peptide, Tsk7L Peptide, actri Peptide, acvr1 Peptide, acvr1-a Peptide, acvr1-b Peptide, acvr1a Peptide, acvrlk2 Peptide, alk-2 Peptide, alk2 Peptide, alk8 Peptide, fop Peptide, sax Peptide, skr1 Peptide, tsri Peptide, xALK-2 Peptide, activin A receptor type 1 Peptide, activin A receptor, type 1 Peptide, activin A receptor type 1 S homeolog Peptide, ACVR1 Peptide, Acvr1 Peptide, acvr1.S Peptide
- Background
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Activin receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. ACVR1 is activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors.Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors.
Alias Symbols: ACTRI, ACVRLK2, ALK2, FOP, SKR1, TSRI, ACVR1A
Protein Interaction Partner: AP2B1,BMP2,BMP7,CDK14,CHN1,CREBBP,DCAF6,DUSP13,ENG,FANCL,FBXO30,FCHO1,FGD6,FKBP4,FNTA,GDF5,IGSF1,IKBKB,INHBA,INHBB,INHBC,KLHL35,NEK8,NKIRAS1,NRAS,NUAK2,PAK1,PLEK,PLEKHB1,PLEKHJ1,RAB17,RAB25,RAB33B,RAB3B,RAB6B,RAP2A,RASD2,RASL12,RHEBL1,RHOD,RHOJ,RPS27A,RRAS2,RXRA,SMAD1,SMAD5,SMAD9,SOCS6,STX8,TGFBR1,THRB,TTC17,TTC27,UBA52,UBE2E3,UBXN1,USP39,VDR,VEPH1,WDR61,ACVR1B,Ap2b1,BMP7,BMPR2,Cdk14,Chn1,ENG,FNTA,Fancl,Fbxo3,Fcho1,Fgd6,Fkbp4,GDF5,Ikbkb,Ilkap,Jub,Naa20,Nkiras1,Nras,Nuak2,Plek,Plekhb1,Rab17,Rab33b,Rab3b,Rab6b,Rap2a,Rasd2,Rhebl1,Rhobtb1,Rhod,Rhoj,Rps27a,Rras2,SMAD1,SMAD5,Sqstm1,Stat1,Stx8,TGFBR2,Tgfbr1,Ube2e3,Ube2r2,Uhmk1,Usp21,Usp39,Wdr61
Protein Size: 509 - Molecular Weight
- 55 kDa
- Gene ID
- 90
- NCBI Accession
- NM_001105, NP_001096
- UniProt
- Q04771
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