Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) Peptide
CDKN1B
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all CDKN1B products
- CDKN1B (Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B))
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-CDKN1B antibody (Catalog #: AVARP03039_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- CDKN1B (Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B))
- Synonyms
- CDKN4 Peptide, KIP1 Peptide, MEN1B Peptide, MEN4 Peptide, P27KIP1 Peptide, cdkn1b Peptide, sb:cb611 Peptide, wu:fb63g10 Peptide, wu:fb64g10 Peptide, wu:fe18e03 Peptide, CDKN1B Peptide, Kip1 Peptide, p27 Peptide, FAM14D Peptide, ISG12 Peptide, ISG12A Peptide, P27 Peptide, Cdki1b Peptide, AA408329 Peptide, AI843786 Peptide, p27Kip1 Peptide, cdkn1bl Peptide, cyclin dependent kinase inhibitor 1B Peptide, cyclin-dependent kinase inhibitor 1Bb Peptide, interferon alpha inducible protein 27 Peptide, cyclin-dependent kinase inhibitor 1B Peptide, cyclin-dependent kinase inhibitor 1Ba Peptide, CDKN1B Peptide, cdkn1bb Peptide, IFI27 Peptide, Cdkn1b Peptide, cdkn1ba Peptide
- Background
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CDKN1B is a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. It binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CDKN4, KIP1, MEN1B, MEN4, P27KIP1
Protein Interaction Partner: FOXO3,CCNA1,CCNA2,CCNA2,CCNA2,CCND1,CCNE1,CCNE1,CDK2,CDK2,CDK2,COPS5,E1A,E1A,KPNA2,SKP2,SKP2,STMN1,UBB,XPO1,ABL1,AKT1,ARHGDIA,CASP8,CCNA1,CCNA2,CCNB1,CCND1,CCND2,CCND3,CCNE2,CDK2,CDK3,CDK4,CDK5,CKS1B,COPS5,CUL4A,GRB2,KPNA3,KPNA5,LYN,MCM7,NUP50,SKP2,SRC,STMN1,TRAF2,TSC2,UBB,UCHL1,XPO1,YES1,YWHAB,YWHAE,YWHAG,YWHAH,YWHAQ,AKT1,ARHGDIA,CCNA1,CCNA2,CCND1,CCND2,CCND3,CCNE1,CDC34,CDK2,CDK4,CDK6,CKS1B,COPS5,CUL4A,GRB2,NUP50,SKP2,SPDYA,TRAF2,TSC1,TSC2,UBE2B,UBE2D2,UCHL1,XPO1,YWHAQ
Protein Size: 198 - Molecular Weight
- 22 kDa
- Gene ID
- 1027
- NCBI Accession
- NM_004064, NP_004055
- UniProt
- P46527
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