Cholinergic Receptor, Nicotinic, beta 3 (Neuronal) (CHRNB3) Peptide
CHRNB3
Reactivity: Human
Host: Synthetic
BP, WB
-
- Target See all CHRNB3 products
- CHRNB3 (Cholinergic Receptor, Nicotinic, beta 3 (Neuronal) (CHRNB3))
- Origin
- Human
-
Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-CHRNB3 antibody (Catalog #: AVARP13021_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
-
Cholinergic Receptor, Nicotinic, beta 3 (Neuronal) (CHRNB3) peptide
CHRNB3 Reactivity: Human, Mouse, Rat Host: Synthetic BP, Imm
-
- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
- Target
- CHRNB3 (Cholinergic Receptor, Nicotinic, beta 3 (Neuronal) (CHRNB3))
- Synonyms
- 5730417K16Rik Peptide, Acrb3 Peptide, NACHR Peptide, CHRNB3 Peptide, chrnb3 Peptide, cholinergic receptor nicotinic beta 3 subunit Peptide, neuronal acetylcholine receptor subunit beta-3 Peptide, cholinergic receptor, nicotinic, beta polypeptide 3 Peptide, cholinergic receptor, nicotinic beta 3 L homeolog Peptide, cholinergic receptor, nicotinic beta 3 Peptide, cholinergic receptor, nicotinic, beta 3b (neuronal) Peptide, cholinergic receptor, nicotinic, beta polypeptide 3a Peptide, CHRNB3 Peptide, CpipJ_CPIJ012638 Peptide, Chrnb3 Peptide, chrnb3.L Peptide, chrnb3 Peptide, chrnb3b Peptide, chrnb3a Peptide
- Background
-
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels nAChRs are pentameric structures that are made up of combinations of individual subunits. CHRNB3 is one of the subunits of nAChR. Twelve neuronal nAChR subunits have been described, alpha2-alpha10 and beta2-beta4. CHRNB3 decreased the channel mean open time and burst length. There was also an increase in single channel slope conductance. On the other hand, the calcium permeability and the pharmacological properties of beta3-containing receptors differed little from those of without beta3. Dysfunction of nAChR has been linked to a number of human diseases such as schizophrenia, Alzheimer's and Parkinson's diseases. nAChRs also play a significant role in nicotine addiction.
Protein Size: 458 - Molecular Weight
- 53 kDa
- Gene ID
- 1142
- NCBI Accession
- NM_000749, NP_000740
- UniProt
- Q05901
-
You are here:
