Cytoplasmic FMR1 Interacting Protein 1 (CYFIP1) (C-Term) Peptide
CYFIP1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all CYFIP1 products
- CYFIP1 (Cytoplasmic FMR1 Interacting Protein 1 (CYFIP1))
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- WAGCMIIVLL GQQRRFAVLD FCYHLLKVQK HDGKDEIIKN VPLKKMVERI
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-CYFIP1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- CYFIP1 (Cytoplasmic FMR1 Interacting Protein 1 (CYFIP1))
- Synonyms
- TUBGCP5 Peptide, P140SRA-1 Peptide, SHYC Peptide, SRA1 Peptide, E030028J09Rik Peptide, P140sra1 Peptide, Shyc Peptide, Sra-1 Peptide, Sra1 Peptide, l(7)1Rl Peptide, l71Rl Peptide, l7Rl1 Peptide, mKIAA0068 Peptide, pl-1 Peptide, CY Peptide, CYFIP Peptide, fb15a06 Peptide, wu:fb15a06 Peptide, cytoplasmic FMR1 interacting protein 1 Peptide, CYFIP1 Peptide, cyfip1 Peptide, Cyfip1 Peptide
- Background
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CYFIP1 is a component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. CYFIP1 promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA By similarity. CYFIP1 regulates formation of membrane ruffles and lamellipodia. CYFIP1 plays a role in axon outgrowth. CYFIP1 binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. CYFIP1 may act as an invasion suppressor in cancers.
Alias Symbols: FLJ45151, P140SRA-1, SHYC, SRA1
Protein Size: 1253 - Molecular Weight
- 145 kDa
- Gene ID
- 23191
- NCBI Accession
- NM_014608, NP_055423
- UniProt
- Q7L576
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