Second Mitochondria-Derived Activator of Caspase (DIABLO) Peptide
DIABLO
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all DIABLO products
- DIABLO (Second Mitochondria-Derived Activator of Caspase (DIABLO))
- Origin
- Human
- Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-DIABLO antibody (Catalog #: AVARP02023_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- DIABLO (Second Mitochondria-Derived Activator of Caspase (DIABLO))
- Synonyms
- smac Peptide, smac3 Peptide, diablo-s Peptide, 0610041G12Rik Peptide, 1700006L01Rik Peptide, AU040403 Peptide, Smac Peptide, DFNA64 Peptide, SMAC Peptide, DBO Peptide, XSmac Peptide, diablo, IAP-binding mitochondrial protein Peptide, diablo IAP-binding mitochondrial protein Peptide, diablo, IAP-binding mitochondrial protein L homeolog Peptide, diablo Peptide, Diablo Peptide, DIABLO Peptide, diablo.L Peptide
- Background
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DIABLO is an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Several alternatively spliced transcript variants that encode distinct isoforms have been described for this gene but the validity of some transcripts, and their predicted ORFs, has not been determined conclusively.
Alias Symbols: SMAC, SMAC3, DFNA64, DIABLO-S
Protein Interaction Partner: BIRC6,BIRC6,LTBR,NGFRAP1,XIAP,XIAP,BIRC2,BIRC3,BIRC5,BIRC6,BIRC7,CASP9,DIABLO,HTRA2,LTBR,NGFRAP1,XIAP,BIRC2,BIRC3,BIRC5,DIABLO,LTBR,NAIP,TNFSF14,USP13,XIAP
Protein Size: 186 - Molecular Weight
- 21 kDa
- Gene ID
- 56616
- NCBI Accession
- NM_138930, NP_620308
- UniProt
- Q502X2
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