Dysferlin (DYSF) (Middle Region) Peptide
DYSF
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all Dysferlin (DYSF) products
- Dysferlin (DYSF)
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-DYSF antibody (Catalog #: ARP45478_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- Dysferlin (DYSF)
- Synonyms
- DYSF Peptide, fb73b05 Peptide, wu:fb73b05 Peptide, si:rp71-50c18.1 Peptide, DKFZp459E1226 Peptide, 2310004N10Rik Peptide, AI604795 Peptide, D6Pas3 Peptide, mFLJ00175 Peptide, FER1L1 Peptide, LGMD2B Peptide, MMD1 Peptide, dysferlin Peptide, dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive) Peptide, myoferlin Peptide, DYSF Peptide, dysf Peptide, LOC589501 Peptide, Dysf Peptide
- Background
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DYSF belongs to the ferlin family and is a skeletal muscle protein found associated with the sarcolemma. It is involved in muscle contraction and contains C2 domains that play a role in calcium-mediated membrane fusion events, suggesting that it may be involved in membrane regeneration and repair. In addition, DYSF binds caveolin-3, a skeletal muscle membrane protein which is important in the formation of caveolae. Specific mutations in this gene have been shown to cause autosomal recessive limb girdle muscular dystrophy type 2B (LGMD2B) as well as Miyoshi myopathy.The protein encoded by this gene belongs to the ferlin family and is a skeletal muscle protein found associated with the sarcolemma. It is involved in muscle contraction and contains C2 domains that play a role in calcium-mediated membrane fusion events, suggesting that it may be involved in membrane regeneration and repair. In addition, the protein encoded by this gene binds caveolin-3, a skeletal muscle membrane protein which is important in the formation of caveolae. Specific mutations in this gene have been shown to cause autosomal recessive limb girdle muscular dystrophy type 2B (LGMD2B) as well as Miyoshi myopathy. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: FER1L1, FLJ00175, FLJ90168, LGMD2B, MMD1
Protein Interaction Partner: ANXA1,ANXA2,CAPN3,CAV3,CAV3
Protein Size: 2080 - Molecular Weight
- 237 kDa
- Gene ID
- 8291
- NCBI Accession
- NM_003494, NP_003485
- UniProt
- O75923
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