IRF1 is interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion.
Alias Symbols: IRF-1, MAR
Protein Interaction Partner: CSNK2A1,CSNK2B,CTDP1,DR1,DRAP1,ERCC3,GTF2F1,MED23,POLR2D,POLR2D,SUB1,TBP,E6,EP300,HMGA1,IRF8,KAT2B,NFKB1,RELA,STAT1,CREBBP,EP300,HMGA1,IRF8,IRF9,KAT2A,KAT2B,SMARCA4,STAT1,STUB1,UBC,tat
Protein Size: 325