Growth Arrest and DNA-Damage-Inducible, gamma Interacting Protein 1 (GADD45GIP1) (Middle Region) Peptide
GADD45GIP1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all GADD45GIP1 products
- GADD45GIP1 (Growth Arrest and DNA-Damage-Inducible, gamma Interacting Protein 1 (GADD45GIP1))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- SLRVKQLAEE QKRREREQHI AECMAKMPQM IVNWQQQQRE NWEKAQADKE
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-GADD45GIP1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- GADD45GIP1 (Growth Arrest and DNA-Damage-Inducible, gamma Interacting Protein 1 (GADD45GIP1))
- Synonyms
- si:dkey-194e13.6 Peptide, CKBBP2 Peptide, CRIF1 Peptide, PLINP Peptide, PLINP-1 Peptide, PRG6 Peptide, Plinp1 Peptide, 2310040G17Rik Peptide, AI425883 Peptide, Crif1 Peptide, growth arrest and DNA-damage-inducible, gamma interacting protein 1 Peptide, GADD45G interacting protein 1 Peptide, gadd45gip1 Peptide, GADD45GIP1 Peptide, Gadd45gip1 Peptide
- Background
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GADD45GIP1 acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. GADD45GIP1 acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. GADD45GIP1 may be involved in the hormone-mediated regulation of NR4A1 transcriptional activity.
Alias Symbols: CKBBP2, CRIF1, MGC4667, MGC4758, PLINP-1, PRG6, Plinp1
Protein Interaction Partner: GADD45A,GADD45B,GADD45G,CSNK2B,EXOSC4,GADD45A,GADD45B,GADD45G,NR4A1,AR,CSNK2B,GADD45A,GADD45B,GADD45G,IKBKG,NR4A1,Nr4a1
Protein Size: 222 - Molecular Weight
- 24 kDa
- Gene ID
- 90480
- NCBI Accession
- NM_052850, NP_443082
- UniProt
- Q8TAE8
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