Hypoxia Up Regulated 1 (HYOU1) (Middle Region) Peptide
HYOU1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all HYOU1 products
- HYOU1 (Hypoxia Up Regulated 1 (HYOU1))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- DREVQYLLNK AKFTKPRPRP KDKNGTRAEP PLNASASDQG EKVIPPAGQT
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-HYOU1 Antibody(ARP46716_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- HYOU1 (Hypoxia Up Regulated 1 (HYOU1))
- Synonyms
- GRP-170 Peptide, Grp170 Peptide, HSP12A Peptide, ORP-150 Peptide, ORP150 Peptide, AI415631 Peptide, CBP-140 Peptide, Cab140 Peptide, Orp150 Peptide, id:ibd5056 Peptide, wu:fd14c05 Peptide, zgc:56019 Peptide, HYOU1 Peptide, orp150 Peptide, GRP170 Peptide, hypoxia up-regulated 1 Peptide, hypoxia up-regulated protein 1 Peptide, hypoxia up-regulated 1 S homeolog Peptide, HYOU1 Peptide, Hyou1 Peptide, hyou1 Peptide, LOC100380749 Peptide, hyou1.S Peptide
- Background
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The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal.
Alias Symbols: DKFZp686N08236, ORP150, Grp170, HSP12A
Protein Interaction Partner: EXT2,IKBKE
Protein Size: 999 - Molecular Weight
- 108 kDa
- Gene ID
- 10525
- NCBI Accession
- NM_006389, NP_006380
- UniProt
- Q9Y4L1
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