Junction Mediating and Regulatory Protein, P53 Cofactor (JMY) (N-Term) Peptide
JMY
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all JMY products
- JMY (Junction Mediating and Regulatory Protein, P53 Cofactor (JMY))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- VFIVAWNEIE GKFAITCHNR TAQRQRSGSR EQAGARGGAE AGGAASDGSR
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-JMY Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- JMY (Junction Mediating and Regulatory Protein, P53 Cofactor (JMY))
- Synonyms
- WHDC1L3 Peptide, junction mediating and regulatory protein, p53 cofactor Peptide, junction-mediating and regulatory protein Peptide, JMY Peptide, jmy Peptide, Jmy Peptide
- Background
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JMY acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, JMY acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. JMY increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, JMY acts as a nucleation-promoting factor for both branched and unbranched actin filaments. JMY activates the Arp2/3 complex to induce branched actin filament networks. JMY also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. JMY contributes to cell motility by controlling actin dynamics. JMY may promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location.
Alias Symbols: FLJ37870, MGC163496, WHDC1L3
Protein Interaction Partner: EP300,MDM2,E2F1,E2F2,E2F3,E2F4,EP300
Protein Size: 712 - Molecular Weight
- 82 kDa
- Gene ID
- 133746
- NCBI Accession
- NM_152405, NP_689618
- UniProt
- Q8N9B5
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