Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1) (C-Term) Peptide
KLRK1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all KLRK1 products
- KLRK1 (Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1))
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- YESQASCMSQ NASLLKVYSK EDQDLLKLVK SYHWMGLVHI PTNGSWQWED
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-KLRK1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- KLRK1 (Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1))
- Synonyms
- KLRK1 Peptide, NKG2D Peptide, CD314 Peptide, D12S2489E Peptide, KLR Peptide, NKG2-D Peptide, D6H12S2489E Peptide, Nkg2d Peptide, Nkrp2 Peptide, killer cell lectin like receptor K1 Peptide, killer cell lectin-like receptor subfamily K, member 1 Peptide, NKG2D protein Peptide, KLRK1 Peptide, Klrk1 Peptide, NKG2D Peptide
- Background
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Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster.
Alias Symbols: CD314, D12S2489E, FLJ17759, FLJ75772, KLR, NKG2-D, NKG2D
Protein Interaction Partner: HCST,HLA-B,KLRK1,MICB,RAET1E,RAET1G,TYROBP,ULBP3,HCST,RAE1
Protein Size: 216 - Molecular Weight
- 24 kDa
- Gene ID
- 22914
- NCBI Accession
- NM_007360, NP_031386
- UniProt
- P26718
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