LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1) (Middle Region) Peptide
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- Target See all LIMS1 products
- LIMS1 (LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- HLCRPCHNRE KARGLGKYIC QKCHAIIDEQ PLIFKNDPYH PDHFNCANCG
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-LIMS1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- LIMS1 (LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1))
- Synonyms
- PINCH Peptide, PINCH-1 Peptide, PINCH1 Peptide, Pinch1 Peptide, RGD1560732 Peptide, LIMS3 Peptide, LIMS3L Peptide, 2310016J22Rik Peptide, 4921524A02Rik Peptide, AI507642 Peptide, AU021743 Peptide, AW551584 Peptide, C430041B13Rik Peptide, Lims1l Peptide, LIM zinc finger domain containing 1 Peptide, LIM and senescent cell antigen-like domains 1 Peptide, LIMS1 Peptide, Lims1 Peptide
- Background
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The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: PINCH, PINCH1
Protein Size: 387 - Molecular Weight
- 44 kDa
- Gene ID
- 3987
- NCBI Accession
- NM_001193485, NP_001180414
- UniProt
- B7Z7R3
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