Low Density Lipoprotein Receptor-Related Protein 8, Apolipoprotein E Receptor (LRP8) (Middle Region) Peptide
LRP8
Reactivity: Mouse
Host: Synthetic
BP, WB
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- Target See all LRP8 products
- LRP8 (Low Density Lipoprotein Receptor-Related Protein 8, Apolipoprotein E Receptor (LRP8))
- Protein Region
- Middle Region
- Origin
- Mouse
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- AGLNGADRQT LVSDNIEWPN GITLDLLSQR LYWVDSKLHQ LSSIDFNGGN
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-Lrp8 Antibody(ARP44306_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- LRP8 (Low Density Lipoprotein Receptor-Related Protein 8, Apolipoprotein E Receptor (LRP8))
- Synonyms
- LRP8 Peptide, APOER2 Peptide, HSZ75190 Peptide, LRP-8 Peptide, MCI1 Peptide, 4932703M08Rik Peptide, AA921429 Peptide, AI848122 Peptide, ApoER2 Peptide, Lr8b Peptide, LR8B Peptide, LDL receptor related protein 8 Peptide, low density lipoprotein receptor-related protein 8, apolipoprotein e receptor Peptide, LRP8 Peptide, Lrp8 Peptide
- Background
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Lrp8 is the cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Lrp8 binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Lrp8 is highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. Lrp8 may also function as an endocytic receptor.
Alias Symbols: 4932703M08Rik, AA921429, AI848122, Lr8b, apoER2, ApoER2
Protein Interaction Partner: Dab1,Dab1,Dab1,Mapk8ip1,Mapk8ip2,Snx17,Dab1
Protein Size: 996 - Molecular Weight
- 110 kDa
- Gene ID
- 16975
- NCBI Accession
- NM_053073, NP_444303
- UniProt
- Q924X6
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