Transcription Factor MafA (MAFA) (Middle Region) Peptide
MAFA
Reactivity: Mouse
Host: Synthetic
BP, WB
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- Target See all MAFA products
- MAFA (Transcription Factor MafA (MAFA))
- Protein Region
- Middle Region
- Origin
- Mouse
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- GGGSAAQAGG APGPPSGGPG TVGGASGKAV LEDLYWMSGY QHHLNPEALN
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-Mafa Antibody(ARP37615_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- MAFA (Transcription Factor MafA (MAFA))
- Synonyms
- RIPE3b1 Peptide, hMafA Peptide, RGD1562627 Peptide, 2F1-Ag Peptide, MAFA Peptide, MAFA-L Peptide, SMaf1 Peptide, mafl Peptide, L-MAF Peptide, MAFL Peptide, Maf Peptide, v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian) Peptide, MAF bZIP transcription factor A Peptide, killer cell lectin-like receptor subfamily G, member 1 Peptide, v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A Peptide, v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Aa Peptide, monocyte to macrophage differentiation-associated Peptide, Mafa Peptide, MAFA Peptide, Klrg1 Peptide, mafa Peptide, mafaa Peptide, Mmd Peptide
- Background
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Mafa acts as a transcriptional factor. Mafa specifically binds the insulin enhancer element RIPE3b. Mafa cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its oncogenic activity. Mafa regulates the insulin gene transcription. Mafa is involved either as an oncogene or as a tumor suppressor, depending on the cell context.
Alias Symbols: RIPE3b1
Protein Size: 359 - Molecular Weight
- 37 kDa
- Gene ID
- 378435
- NCBI Accession
- NM_194350, NP_919331
- UniProt
- Q8CF90
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