Paired Immunoglobin-Like Type 2 Receptor alpha (PILRA) Peptide
PILRA
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all PILRA products
- PILRA (Paired Immunoglobin-Like Type 2 Receptor alpha (PILRA))
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-PILRA antibody (Catalog #: ARP46947_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- PILRA (Paired Immunoglobin-Like Type 2 Receptor alpha (PILRA))
- Synonyms
- PILRA Peptide, FDF03 Peptide, AV021745 Peptide, RGD1562847 Peptide, paired immunoglobin like type 2 receptor alpha Peptide, paired immunoglobulin-like type 2 receptor alpha Peptide, paired immunoglobin-like type 2 receptor alpha Peptide, PILRA Peptide, LOC489841 Peptide, Pilra Peptide
- Background
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Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role.Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described.
Alias Symbols: FDF03
Protein Interaction Partner: FCAR,PTPN11,PTPN6,PTPN11,PTPN6
Protein Size: 175 - Molecular Weight
- 18 kDa
- Gene ID
- 29992
- NCBI Accession
- NM_178273, NP_840057
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