Pyruvate Kinase, Liver and RBC (PKLR) Peptide
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- Target See all PKLR products
- PKLR (Pyruvate Kinase, Liver and RBC (PKLR))
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-PKLR antibody (Catalog #: ARP41699_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- PKLR (Pyruvate Kinase, Liver and RBC (PKLR))
- Synonyms
- PK1 Peptide, PKL Peptide, PKR Peptide, PKRL Peptide, RPK Peptide, Pklg Peptide, wu:fd15e01 Peptide, wu:fi37e08 Peptide, pk1 Peptide, PKLR Peptide, Pk-1 Peptide, Pk1 Peptide, R-PK Peptide, pklr Peptide, pyruvate kinase L/R Peptide, pyruvate kinase, liver and RBC Peptide, pyruvate kinase, liver and RBC L homeolog Peptide, pyruvate kinase liver and red blood cell Peptide, pyruvate kinase PKLR-like Peptide, PKLR Peptide, Pklr Peptide, pklr Peptide, pklr.L Peptide, LOC100621940 Peptide
- Background
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PKLR is a pyruvate kinase that catalyzes the production of phohsphoenolpyruvate from pyruvate and ATP. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA).The protein encoded by this gene is a pyruvate kinase that catalyzes the production of phohsphoenolpyruvate from pyruvate and ATP. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Alternatively spliced transcript variants encoding distinct isoforms have been described.
Alias Symbols: PK1, PKL, RPK, PKR, PKRL
Protein Interaction Partner: MYOC,ARHGEF6,KIF23,OTUD5,PAK1,PXN,USP3,USPL1
Protein Size: 543 - Molecular Weight
- 58 kDa
- Gene ID
- 5313
- NCBI Accession
- NM_181871, NP_870986
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