Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1) (N-Term) Peptide
PLEKHO1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all PLEKHO1 products
- PLEKHO1 (Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- MMKKNNSAKR GPQDGNQQPA PPEKVGWVRK FCGKGIFREI WKNRYVVLKG
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-PLEKHO1 Antibody(ARP47817_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- PLEKHO1 (Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1))
- Synonyms
- CKIP-1 Peptide, OC120 Peptide, 2810052M02Rik Peptide, Ckip1 Peptide, JZA-20 Peptide, Jza2 Peptide, RGD1311487 Peptide, ckip-1 Peptide, plekho1 Peptide, si:dkey-200h23.2 Peptide, pleckstrin homology domain containing O1 Peptide, pleckstrin homology domain containing, family O member 1 Peptide, pleckstrin homology domain containing, family O member 1a Peptide, PLEKHO1 Peptide, Plekho1 Peptide, plekho1a Peptide
- Background
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PLEKHO1 plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP).PLEKHO1 may function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). PLEKHO1 appears to target ATM to the plasma membrane. PLEKHO1 appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. PLEKHO1 is also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.
Alias Symbols: CKIP-1, OC120, RP11-458I7.3
Protein Interaction Partner: CSNK2A1,SMURF1,USP7,CASP3,JUN,JUND,PLEKHO1,CSNK2A1,SMAD5,SMURF1
Protein Size: 409 - Molecular Weight
- 46 kDa
- Gene ID
- 51177
- NCBI Accession
- NM_016274, NP_057358
- UniProt
- Q53GL0
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