Pre-mRNA Processing Factor 19 (PRPF19) Peptide
PRPF19
Reactivity: Human
Host: Synthetic
BP, WB, IHC
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- Target See all PRP19 (PRPF19) products
- PRP19 (PRPF19) (Pre-mRNA Processing Factor 19 (PRPF19))
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-PRPF19 antibody (Catalog #: ARP43158_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- PRP19 (PRPF19) (Pre-mRNA Processing Factor 19 (PRPF19))
- Synonyms
- NMP200 Peptide, fb18f09 Peptide, zgc:56158 Peptide, wu:fb18f09 Peptide, nmp200 Peptide, PRP19 Peptide, PSO4 Peptide, SNEV Peptide, UBOX4 Peptide, hPSO4 Peptide, Prp19 Peptide, nmp-200 Peptide, AA617263 Peptide, AL024362 Peptide, D19Wsu55e Peptide, Snev Peptide, pre-mRNA processing factor 19 Peptide, pre-mRNA processing factor 19 L homeolog Peptide, prpf19 Peptide, prpf19.L Peptide, PRPF19 Peptide, Prpf19 Peptide
- Background
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PRPF19 plays a role in DNA double-strand break (DSB) repair and pre-mRNA splicing reaction. It binds double-stranded DNA in a sequence-nonspecific manner. PRPF19 acts as a structural component of the nuclear framework. It may also serve as a support for spliceosome binding and activity. It is essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. It also may have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Overexpression of PRPF19 might extend the cellular life span by increasing the resistance to stress or by improving the DNA repair capacity of the cells.In S. cerevisiae, Pso4 has pleiotropic functions in DNA recombination and in error-prone nonhomologous end-joining DNA repair.[supplied by OMIM].
Alias Symbols: NMP200, PRP19, PSO4, UBOX4, hPSO4, SNEV
Protein Interaction Partner: DNTT,EXOC7,CDC5L,DNTT,EXOC7,PLRG1
Protein Size: 504 - Molecular Weight
- 55 kDa
- Gene ID
- 27339
- NCBI Accession
- NM_014502, NP_055317
- UniProt
- Q9UMS4
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