Proteasome (Prosome, Macropain) Activator Subunit 2 (PA28 Beta) (PSME2) (Middle Region) Peptide
PSME2
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all PSME2 products
- PSME2 (Proteasome (Prosome, Macropain) Activator Subunit 2 (PA28 Beta) (PSME2))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- QEKVLERVNA VKTKVEAFQT TISKYFSERG DAVAKASKET HVMDYRALVH
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-PSME2 Antibody(ARP56485_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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Proteasome (Prosome, Macropain) Activator Subunit 2 (PA28 Beta) (PSME2) peptide
PSME2 Reactivity: Human, Dog, Mouse, Rat Host: Synthetic BP, Imm
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- PSME2 (Proteasome (Prosome, Macropain) Activator Subunit 2 (PA28 Beta) (PSME2))
- Synonyms
- unp309 Peptide, PA28B Peptide, PA28beta Peptide, REGbeta Peptide, AA589371 Peptide, AI788882 Peptide, PA28b Peptide, proteasome activator subunit 2 Peptide, proteasome (prosome, macropain) activator subunit 2 (PA28 beta) Peptide, psme2 Peptide, PSME2 Peptide, Psme2 Peptide
- Background
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The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the beta subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three beta and three alpha subunits combine to form a heterohexameric ring. Six pseudogenes have been identified on chromosomes 4, 5, 8, 10 and 13.
Alias Symbols: PA28B, PA28beta, REGbeta
Protein Interaction Partner: PSME1,PSME2,PSME1,PSME2
Protein Size: 239 - Molecular Weight
- 27 kDa
- Gene ID
- 5721
- NCBI Accession
- NM_002818, NP_002809
- UniProt
- Q9UL46
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