Prostaglandin I2 (Prostacyclin) Synthase (PTGIS) (Middle Region) Peptide
PTGIS
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all PTGIS products
- PTGIS (Prostaglandin I2 (Prostacyclin) Synthase (PTGIS))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-PTGIS antibody (Catalog #: ARP44377_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- PTGIS (Prostaglandin I2 (Prostacyclin) Synthase (PTGIS))
- Synonyms
- CYP8 Peptide, CYP8A1 Peptide, PGIS Peptide, PTGI Peptide, Cyp8 Peptide, Cyp8a1 Peptide, Pgis Peptide, ptgisl Peptide, PTGIS Peptide, prostaglandin I2 synthase Peptide, prostaglandin I2 (prostacyclin) synthase Peptide, prostacyclin synthase Peptide, PTGIS Peptide, Ptgis Peptide, ptgis Peptide, VDBG_06319 Peptide
- Background
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PTGIS is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CYP8, CYP8A1, MGC126858, MGC126860, PGIS, PTGI
Protein Size: 500 - Molecular Weight
- 57 kDa
- Gene ID
- 5740
- NCBI Accession
- NM_000961, NP_000952
- UniProt
- Q16647
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