PTK2B Protein tyrosine Kinase 2 beta (PTK2B) Peptide
PTK2B
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all PTK2B products
- PTK2B (PTK2B Protein tyrosine Kinase 2 beta (PTK2B))
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-PTK2B antibody (Catalog #: ARP32685_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- PTK2B (PTK2B Protein tyrosine Kinase 2 beta (PTK2B))
- Synonyms
- CADTK Peptide, CAKB Peptide, FADK2 Peptide, FAK2 Peptide, PKB Peptide, PTK Peptide, PYK2 Peptide, RAFTK Peptide, CAKbeta Peptide, E430023O05Rik Peptide, Raftk Peptide, Pyk2 Peptide, fak1b Peptide, ptk2.2 Peptide, ptk2b Peptide, si:ch1073-355e8.1 Peptide, protein tyrosine kinase 2 beta Peptide, PTK2 protein tyrosine kinase 2 beta Peptide, protein tyrosine kinase 2aa Peptide, PTK2B Peptide, Ptk2b Peptide, ptk2aa Peptide
- Background
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PTK2B encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies.
Alias Symbols: PKB, PTK, CAKB, FAK2, PYK2, CADTK, FADK2, RAFTK
Protein Interaction Partner: SORBS2,ARHGAP21,ARHGAP5,ASAP1,ASAP2,BCAR1,CBL,CCR5,CRK,DLG3,DLG4,DLGAP3,EFS,EGFR,ERBB2,ERBB3,EWSR1,FGFR2,FGFR3,FLT1,FYN,GNA13,GRB2,GRIN2A,GSN,IL7R,ITGB2,ITGB3,JAK1,JAK2,JAK3,KCNA2,LCK,LPXN,LYN,MAP3K4,MATK,MCAM,MYH2,NEDD9,NPHP1,PDCD6IP,PDPK1,PIK3R1,PITPNM1,PITPNM2,PITPNM3,PRKCD,PTK2,PTK2B,PTK2B,PTPN11,PTPN12,PTPN6,PXN,RASA1,RB1CC1,SH2D3C,SHC1,SLC2A1,SNCA,SORBS2,SRC,STAP1,STAT3,SYK,TGFB1I1,TLN1,VAV1,ZAP70,ASAP2,BCAR1,CBL,CD2AP,DCC,DLG3,DLG4,EGFR,ERBB2,EWSR1,FYN,GIT1,GNA13,GRB2,GRIN2A,GSN,IL7R,ITGB2,ITGB3,JAK1,JAK2,JAK3,KCNA2,LCK,LPXN,LYN,NEDD9,NPHP1,PITPNM1,PITPNM2,PITPNM3,PRKCD,PTK2B,PTPN11,PTPN12,PTPN6,PXN,RASA1,RB1CC1,SLC2A1,SOCS3,SORBS1,SORBS2,SRC,SYK,TGFB1I1,TLN1,VAV1
Protein Size: 1009 - Molecular Weight
- 116 kDa
- Gene ID
- 2185
- NCBI Accession
- NM_004103, NP_004094
- UniProt
- Q14289
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