Secretogranin V (7B2 Protein) (SCG5) (C-Term) Peptide
SCG5
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all SCG5 products
- SCG5 (Secretogranin V (7B2 Protein) (SCG5))
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- QHLFDPEHDY PGLGKWNKKL LYEKMKGGER RKRRSVNPYL QGQRLDNVVA
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-SCG5 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- SCG5 (Secretogranin V (7B2 Protein) (SCG5))
- Synonyms
- zgc:73132 Peptide, sgne1 Peptide, MGC145087 Peptide, 7B2 Peptide, AI325031 Peptide, Sgne-1 Peptide, Sgne1 Peptide, P7B2 Peptide, SGNE1 Peptide, SgV Peptide, secretogranin V Peptide, scg5 Peptide, SCG5 Peptide, Scg5 Peptide
- Background
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SCG5 acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. SCG5 binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. SCG5 is also required for cleavage of PCSK2 but does not appear to be involved in its folding. SCG5 plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.
Alias Symbols: 7B2, P7B2, SGNE1, SgV
Protein Interaction Partner: PCSK2,UBQLN4,NR1H2,UBQLN4
Protein Size: 212 - Molecular Weight
- 23 kDa
- Gene ID
- 6447
- NCBI Accession
- NM_001144757, NP_001138229
- UniProt
- P05408
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