Signal-Regulatory Protein alpha (SIRPA) Peptide
SIRPA
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all SIRPA products
- SIRPA (Signal-Regulatory Protein alpha (SIRPA))
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-SIRPA antibody (Catalog #: AVARP00011_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- SIRPA (Signal-Regulatory Protein alpha (SIRPA))
- Synonyms
- BIT Peptide, CD172A Peptide, MFR Peptide, MYD-1 Peptide, P84 Peptide, PTPNS1 Peptide, SHPS1 Peptide, SIRP Peptide, SIRPA Peptide, SIRP-A1 Peptide, SIRP-B1 Peptide, AI835480 Peptide, Bit Peptide, CD172a Peptide, Ptpns1 Peptide, SHP-1 Peptide, SHPS-1 Peptide, swc3 Peptide, signal regulatory protein alpha Peptide, myeloperoxidase Peptide, signal-regulatory protein alpha Peptide, tyrosine-protein phosphatase non-receptor type substrate 1 Peptide, SIRPA Peptide, MPO Peptide, LOC458039 Peptide, LOC100400378 Peptide, LOC100590224 Peptide, Sirpa Peptide
- Background
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SIRPA is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene.
Alias Symbols: BIT, CD172A, MFR, MYD-1, P84, PTPNS1, SHPS-1, SHPS1, SIRP, SIRP-ALPHA-1, SIRPalpha, SIRPalpha2
Protein Interaction Partner: CD47,IL1RAP,JAK2,NOL3,PTPN11,PTPN6,TRIM2,JAK2,NOL3,PTPN6,TRIM2
Protein Size: 504 - Molecular Weight
- 52 kDa
- Gene ID
- 140885
- NCBI Accession
- NM_080792, NP_542970
- UniProt
- B2R6C3
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