SRY (Sex Determining Region Y)-Box 6 (SOX6) (Middle Region) Peptide
SOX6
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all SOX6 products
- SOX6 (SRY (Sex Determining Region Y)-Box 6 (SOX6))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-SOX6 antibody (Catalog #: ARP33148_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- SOX6 (SRY (Sex Determining Region Y)-Box 6 (SOX6))
- Synonyms
- HSSOX6 Peptide, SOXD Peptide, Sox6 Peptide, AI987981 Peptide, SOX-LZ Peptide, fc35a10 Peptide, fc50e03 Peptide, sox-lz Peptide, sox6b Peptide, wu:fc35a10 Peptide, wu:fc50e03 Peptide, SRY-box 6 Peptide, SRY box 6 Peptide, SRY (sex determining region Y)-box 6 Peptide, SOX6 Peptide, Sox6 Peptide, sox6 Peptide
- Background
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SOX6 is a member of the D subfamily of sex determining region y-related transcription factors that are characterized by a conserved DNA-binding domain termed the high mobility group box and by their ability to bind the minor groove of DNA. SOX6 is a transcriptional activator that is required for normal development of the central nervous system, chondrogenesis and maintenance of cardiac and skeletal muscle cells. SOX6 interacts with other family members to cooperatively activate gene expression.Members of the SOX gene family, such as SOX6, encode transcription factors defined by the conserved high mobility group (HMG) DNA-binding domain. Unlike most transcription factors, SOX transcription factors bind to the minor groove of DNA, causing a 70- to 85-degree bend and introducing local conformational changes (Cohen-Barak et al., 2001 [PubMed 11255018]).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-2696 AL136780.1 1-2696 2697-5158 AC009869.7 10394-12855
Alias Symbols: HSSOX6, SOXD
Protein Interaction Partner: CENPK,CTBP2,DAZAP2,SOX5,SOX6,SUMO1,SUMO2,SUMO3,CENPK,CTBP2
Protein Size: 804 - Molecular Weight
- 89 kDa
- Gene ID
- 55553
- NCBI Accession
- NM_017508, NP_059978
- UniProt
- A8MRT1
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