Spleen Focus Forming Virus (SFFV) Proviral Integration Oncogene Spi1 (SPI1) (Middle Region) Peptide
SPI1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all SPI1 products
- SPI1 (Spleen Focus Forming Virus (SFFV) Proviral Integration Oncogene Spi1 (SPI1))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-SPI1 antibody (Catalog #: ARP38241_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- SPI1 (Spleen Focus Forming Virus (SFFV) Proviral Integration Oncogene Spi1 (SPI1))
- Synonyms
- OF Peptide, PU.1 Peptide, SFPI1 Peptide, SPI-1 Peptide, SPI-A Peptide, Dis-1 Peptide, Dis1 Peptide, Sfpi-1 Peptide, Sfpi1 Peptide, Spi-1 Peptide, Tcfpu1 Peptide, Tfpu.1 Peptide, Pu.1 Peptide, cb1086 Peptide, pu.1 Peptide, pu1 Peptide, sfpi1 Peptide, si:by184l24.2 Peptide, spi1 Peptide, SPI1/PU.1 Peptide, spi1l Peptide, zgc:152991 Peptide, Spi-1 proto-oncogene Peptide, spleen focus forming virus (SFFV) proviral integration oncogene Peptide, Spi-1 proto-oncogene b Peptide, Spi-1 proto-oncogene a Peptide, SPI1 Peptide, Spi1 Peptide, spi1b Peptide, spi1a Peptide
- Background
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SPI1 is known to collaborate with multiple transcription factors and to regulate expression of immunoglobulin genes. Lack of SPI1 expression is associated with defective immunoglobulin transcription in Hodgkin and Reed-Sternberg cells of classical Hodgkin disease. This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: OF, PU.1, SFPI1, SPI-1, SPI-A
Protein Interaction Partner: CEBPE,GATA1,PRG2,ATF1,CEBPA,CEBPB,CEBPD,CEBPE,CREBBP,CREM,ERG,FUS,GATA1,GATA2,IRF4,IRF8,JUN,MITF,MYST3,NFATC1,NFKB1,NONO,PIP,RB1,SPIB,SSRP1,TBP,ATF1,CEBPA,CEBPB,CREM,CSNK2A1,DNMT3A,DNMT3B,ETS1,ETS2,ETV1,FOS,FUS,GATA2,HDAC1,IRF4,JUN,MAPK8,MECP2,MITF,NFYA,NONO,SPIB
Protein Size: 270 - Molecular Weight
- 31 kDa
- Gene ID
- 6688
- NCBI Accession
- NM_003120, NP_003111
- UniProt
- P17947
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