Tumor Necrosis Factor Receptor Superfamily, Member 10c (TNFRSF10C) (N-Term) Peptide
TNFRSF10C
Reactivity: Human, Drosophila melanogaster
Host: Synthetic
BP, WB
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- Target See all DcR1 (TNFRSF10C) products
- DcR1 (TNFRSF10C) (Tumor Necrosis Factor Receptor Superfamily, Member 10c (TNFRSF10C))
- Protein Region
- N-Term
- Origin
- Human, Drosophila melanogaster
- Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-TNFRSF10C antibody (Catalog #: AVARP02039_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- DcR1 (TNFRSF10C) (Tumor Necrosis Factor Receptor Superfamily, Member 10c (TNFRSF10C))
- Synonyms
- CD263 Peptide, DCR1 Peptide, DCR1-TNFR Peptide, LIT Peptide, TRAIL-R3 Peptide, TRAILR3 Peptide, TRID Peptide, TNFRSF10C Peptide, TNF receptor superfamily member 10c Peptide, TNFRSF10C Peptide
- Background
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TNFRSF10C is the receptor for the cytotoxic ligand TRAIL. TNFRSF10C lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. TNFRSF10C may protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CD263, DCR1, LIT, MGC149501, MGC149502, TRAILR3, TRID, TRAIL-R3, DCR1-TNFR
Protein Interaction Partner: TP53,APOA1,FAM101B,LRSAM1,RAP1A,SLC27A6,TNFSF10,ZHX1,APOA1,FAM101B,SLC27A6,ZHX1
Protein Size: 259 - Molecular Weight
- 25 kDa
- Gene ID
- 8794
- NCBI Accession
- NM_003841, NP_003832
- UniProt
- O14798
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