Vinculin (VCL) (C-Term) Peptide
VCL
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all Vinculin (VCL) products
- Vinculin (VCL)
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- PRPPPPEEKD EEFPEQKAGE VINQPMMMAA RQLHDEARKW SSKGNDIIAA
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-VCL Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- Vinculin (VCL)
- Synonyms
- CMD1W Peptide, CMH15 Peptide, MV Peptide, MVCL Peptide, VCL Peptide, im:6902790 Peptide, hm:zehn2160 Peptide, DDBDRAFT_0186762 Peptide, DDBDRAFT_0232320 Peptide, DDB_0186762 Peptide, DDB_0232320 Peptide, 9430097D22 Peptide, AA571387 Peptide, AI462105 Peptide, AW545629 Peptide, CG3299 Peptide, CT11081 Peptide, Dmel\\CG3299 Peptide, Dmvincp Peptide, EG:103B4.1 Peptide, Vin Peptide, Vin2EF Peptide, vinc Peptide, LOC100228062 Peptide, vcl-A Peptide, vinculin Peptide, vinculin a Peptide, vinculin A Peptide, Vinculin Peptide, vinculin S homeolog Peptide, VCL Peptide, vcla Peptide, vinA Peptide, Vcl Peptide, Vinc Peptide, CpipJ_CPIJ013873 Peptide, Bm1_37935 Peptide, vcl Peptide, vcl.S Peptide
- Background
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Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.
Alias Symbols: CMD1W, CMH15, MVCL
Protein Interaction Partner: ABI2,ACTA1,ACTN1,C19orf57,CDH1,CLTC,CORO2B,CTNNA1,GSN,NRAP,PKD1,PRKCA,PRPF40A,PSME1,PTK2,PXN,RAVER1,SELE,SORBS1,SORBS2,SRC,TLN1,TRIP6,VASP,ABI2,BCAR1,C19orf57,CDH1,CLTC,CORO2B,CTNNA1,CTNNB1,GSN,NRAP,PSME1,PXN,Raver1,SORBS1,SORBS2,TGFB1I1,TRIP6,VASP
Protein Size: 1066 - Molecular Weight
- 117 kDa
- Gene ID
- 7414
- NCBI Accession
- NM_003373, NP_003364
- UniProt
- P18206
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