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This study demonstrated that a significant decrease in the protein level of GluN2A (show GRIN2A Proteins) in major depression disorder.
both the intracellular C-terminal domain (CTD) and the loop region between the M1 and M2 helices move during activation and the CTD is detached from the membrane
The results of this study suggest that neurons in hypothalamic hamartoma may bear Ca(2 (show CA2 Proteins)+) -permeable AMPA (show GRIA3 Proteins) receptors(GluA2 ) due to dislocation of ADAR2 (show ADARB1 Proteins)
A transient positive feedback mechanism between AMPAR and stargazin has implications for information processing in the brain, because it should allow activity-dependent facilitation of excitatory synaptic transmission through a postsynaptic mechanism.
The GluR2 subunit of the AMPA (show GRIA3 Proteins) receptor is involved in cell migration and calcium signaling.
RAB39B (show RAB39B Proteins) selectively regulates GluA2 trafficking to determine synaptic AMPAR composition
GRIA2*CCC polymorphism is genetic risk marker for paranoid schizophrenia in Russians.Low risk genetic markers of paranoid schizophrenia were revealed: in Tatars-GRIA2*T/T (rs43025506) of GRIA2 gene and GRIA2*CCT in Russians.
GRIA2 is a useful marker for distinguishing solitary fibrous tumour from most mimics
a link between neurodegenerative processes and deficient RNA editing of the GluA2 Q/R site.
the levels were comparable for complexes containing GluR2, GluR3 (show GRIA3 Proteins) and GluR4 (show GRIA4 Proteins) as well as 5-HT1A (show HTR1A Proteins). Moreover, the levels of complexes containing muscarinic AChR M1, NR1 (show GRIN1 Proteins) and GluR1 (show GRIA1 Proteins) were significantly increased in male patients with AD.
The data of this study indicated that GluA2-lacking AMPARs are present at D1R (show DRD1 Proteins)-expressing MSN (show MSN Proteins) synapses after withdrawal from both contingent and non-contingent cocaine exposure.
Topological regulation of synaptic AMPA (show GRIA3 Proteins) receptor expression by the RNA-binding protein CPEB3 (show CPEB3 Proteins) has been demonstrated.
Results indicate that disrupting GluA2 phosphorylation and increasing GluA2-mediated transmission in the nucleus accumbens leads to increased vulnerability to cocaine relapse.
Chronic stress-elicited depressive behavior may be due to hypertrophy of basolateral amygdala (BLA (show LACTB Proteins)) neuronal dendrites and increased of Glur1 (show GRIA1 Proteins)-Glur2 ratio in BLA (show LACTB Proteins) neurons.
found the protein levels of AMPA (show GRIA3 Proteins) receptor subunits (GluR1 (show GRIA1 Proteins) and GluR2) are upregulated in the amygdala and the 5-HT3 receptor (show HTR3A Proteins) is downregulated in hypothalamic regions of Socially Isolated mice.
These results provide direct evidence for cortical AMPA (show GRIA3 Proteins) receptors to contribute to zymosan-induced visceral and spontaneous pain.
Animals trained in the trace fear conditioning protocol had GluA2 RNA editing levels were nearly 100% in amygdala and hippocampus.
These results provide evidence for VPS35 (show vps35 Proteins)'s function in promoting spine maturation, which is likely through increasing AMPA (show GRIA3 Proteins) receptor targeting to the postsynaptic membrane.
Bacopa monnieri extract (CDRI-08) upregulates the expression of the GluR2 subunit in the CA3 (show CA3 Proteins) area of the hippocampus.
subcellular redistribution of GRIP1 (show NCOA2 Proteins) and a change in the binding of GRIP1 (show NCOA2 Proteins) to GluA2 during synaptic scaling, was observed.
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG\; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene.
AMPA-selective glutamate receptor 2
, Glutamate receptor 2
, glutamate receptor ionotropic, AMPA 2
, glutamate receptor 2
, glutamate receptor B
, AMPA glutamate receptor 2
, AMPA receptor GluR2/B
, AMPA selective glutamate receptor
, glutamate receptor AMPA 2