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High HKII expresiion is associated with nasopharyngeal carcinoma.
Results show that the hexokinase 2 (HK2) promoter CpG island (HK2-CGI) surrounding regions N-shore was hypomethylated, thereby enhancing HK2 expression, the HK2-CGI was itself hypermethylated in some hepatocellular carcinomas (HCCs (show HCCS Proteins)).
findings confirmed the tumorigenic activity of HK2 in glioma, and the involvement of the miR218/Bmi1 (show BMI1 Proteins) pathway in the regulation of its expression
BAG3 (show BAG3 Proteins) directly stabilizes hexokinase 2 mRNA and promotes aerobic glycolysis in pancreatic cancer cells.
Previously unknown reciprocal influence of SIRT6 (show SIRT6 Proteins) and HK2 in regulating autophagy driven monocyte differentiation.
SIRT6 (show SIRT6 Proteins) over-expression establishes a condition whereby reconfiguration of the Hexokinase 2 promoter chromatin structure makes it receptive to interaction with MZF1 (show ZFP42 Proteins)/SIRT6 (show SIRT6 Proteins) complex, thereby favouring a regulatory state conducive to diminished transcription
findings suggested that PVT1 contributes to osteosarcoma (OS) cell glucose metabolism, cell proliferation, and motility through the miR (show MLXIP Proteins)-497/HK2 pathway, and revealed a novel relation between lncRNA and the alteration of glycolysis in OS cells
High HKII expression is associated with metastasis and epithelial-mesenchymal transition in hepatocellular carcinoma.
The EML4-ALK-mediated upregulation of HIF1alpha, HK2 and glycolytic metabolism was also highly active in vivo as demonstrated by fluorodeoxyglucose-positron emission tomography imaging of xenografts grown from EML4-ALK-positive NSCLC cells.
relevant number of patients with FDG (show SMUG1 Proteins)-PET false-negative multiple myeloma and a strong association between hexokinase-2 expression and this negativity: a finding which may also be relevant for clinical imaging of other hematological cancers.
changes in mitochondrial HKII modestly affect cardiac oxygen consumption and energy substrate metabolism
Hexokinase expression is highly enriched in neurons compared to astrocytes.
Hexokinase II (HKII) binding to the mitochondria is decreased in muscle from high fat diet-fed SIRT3 (show SIRT3 Proteins) KO mice.
HK2 is upregulated in prostate cancer cells harboring Pten/p53 (show TP53 Proteins) mutations. HK2 is required for Pten-/p53 (show TP53 Proteins)-deficiency-driven prostate tumor growth in vivo.
A lack of effect on gene expression, changes in the protein expression patterns of the key genes GLUT1/SLC2A1 (show SLC2A1 Proteins) and HK2 were observed after radiation treatment.
Both HK2 mRNA and protein were increased under hypoxia, which is accompanied by an increase of glucose uptake and production of lactate.
Suggest that HK2 attenuates cardiac hypertrophy by decreasing ROS (show ROS1 Proteins) accumulation via increased pentose phosphate pathway flux.
phosphorylation-mediated regulation of mitochondrial HK-II would be a critical component of the protective effect of Akt (show AKT1 Proteins).
Reduced muscle HKII protein content results in impaired muscle functionality during recovery from ischemic-reperfusion injury.
The tissue expression profiles of eGYS1, equine type II hexokinase (eHKII) and muscle-type phosphofructokinase (ePFKM) were determined by real-time PCR and western blot analysis.
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells.
, hexokinase type II
, hexokinase-2, muscle
, muscle form hexokinase
, hexokinase II
, hexokinase 2
, likely hexokinase II