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p54 (show DDX6 Proteins)-S6K2 interactome is predominant to the nucleus, whereas p70-S6K1 (show RPS6KB1 Proteins) is predominant to cytosol.
Overexpression of catalytically-active Akt or knockdown of glycogen synthase kinase-3 (GSK3)-beta, a substrate for Akt, had little effect on Mcl-1 downregulation caused by S6K2 deficiency
We propose that the S6K2/TRBP (show TARBP2 Proteins) node controls miRNA biogenesis in HDLECs and provides a molecular link between the mTOR (show FRAP1 Proteins) pathway and the miRNA biogenesis machinery.
discovered that ERBB4 (show ERBB4 Proteins) and S6K2 were the direct targets of miR (show MLXIP Proteins)-193a-3p and that PIK3R3 and mTOR (show FRAP1 Proteins) were the direct targets of miR (show MLXIP Proteins)-193a-5p in non-small-cell lung cancer
Degradation of Tiam1 (show TIAM1 Proteins) by casein kinase 1 (show CSNK1A1 Proteins) and the SCFbetaTrCP ubiquitin ligase controls the duration of mTOR (show FRAP1 Proteins)-S6K (show RPS6KB1 Proteins) signaling.
The mTOR effectors 4EBP1 and S6K2 are frequently coexpressed, and associated with a poor prognosis and endocrine resistance in breast cancer.
The p85 S6K1 (show RPS6KB1 Proteins) promotes H2O2-induced cell death via a rapamycin-insensitive mechanism.
S6K2 amplification was frequently observed in gastric cancer and was related to a poor prognosis
S6K1 and S6K2 gene amplification was associated with a worse prognosis.
S6K2 expression dictates tissue-specific requirement for S6K1 (show RPS6KB1 Proteins) in mediating aberrant mTORC1 signaling and tumorigenesis
S6K2 loss reduces Th17 skewing and increases regulatory T cell differentiation.
the p70S6K (show RPS6KB1 Proteins) isoforms have unique and redundant functions in mediating fibrogenic processes, including proliferation, migration.
S6K2 regulates hepatic energy homeostasis by repressing PPARalpha (show PPARA Proteins) activity.
metabolic functions of S6K (show RPS6KB1 Proteins) in vivo play a key role as a molecular interface connecting dietary lipids to the endogenous control of energy metabolism.
Data show that the absence of ribosomal protein S6 (show RPS6 Proteins) kinases 1 and 2 (S6K1 (show RPS6KB1 Proteins) and S6K2) profoundly impairs animal viability but does not seem to affect the proliferative responses of cells derived from the distinct S6K (show RPS6KB1 Proteins) genotypes.
S6K2 is activated by IL-3 (show IL-3 Proteins) in the IL-3 (show IL-3 Proteins)-dependent Ba/F3 cell line and this is mediated by mTOR (show FRAP1 Proteins) and its upstream activator PI-3K but not by MAPK (show MAPK1 Proteins) signal pathways.
parallel increase in p70S6K (show RPS6KB1 Proteins) activation and tau phosphorylation could be demonstrated by treating wild-type N2a cells with Abeta25-35
mGluR (show GRM8 Proteins)-LTD is associated with PI3K-, mTOR (show FRAP1 Proteins)-, and ERK (show EPHB2 Proteins)-dependent alterations in the phosphorylation of S6 and S6K (show RPS6KB1 Proteins).
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eucaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation.
70 kDa ribosomal protein S6 kinase 2
, S6 kinase-related kinase
, p70 S6 kinase beta
, p70 S6K-beta
, p70 S6KB
, p70 ribosomal S6 kinase beta
, p70-S6K 2
, ribosomal protein S6 kinase beta-2
, serine/threonine-protein kinase 14 beta
, serine/threonine-protein kinase 14B
, ribosomal protein S6 kinase, 70kDa, polypeptide 2
, S6 kinase 2
, ribosomal protein S6 kinase, 70kD, polypeptide 2