anti-Human BRISC and BRCA1 A Complex Member 1 antibody for ELISA

Recommended BRISC and BRCA1 A Complex Member 1 Antibody (supplied by: Log in to see )

Antigen
BRISC and BRCA1 A Complex Member 1 (BABAM1) Antibodies
  • merit40
  • nba1
  • zgc:100909
  • c19orf62
  • C19orf62
  • MERIT40
  • NBA1
  • C7H19orf62
  • 5430437P03Rik
  • Merit40
  • BRISC and BRCA1 A complex member 1
  • BRISC and BRCA1 A complex member 1 L homeolog
  • babam1
  • BABAM1
  • babam1.L
  • Babam1
Epitope
pSer29
11
10
7
4
3
2
2
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
36
4
3
2
2
2
1
1
Host
Rabbit
29
4
2
1
Clonality
Polyclonal
Conjugate
Un-conjugated
2
2
2
2
2
2
Application
ELISA, Western Blotting (WB)
34
20
18
7
4
3
1
1
Options
Supplier
Log in to see
Supplier Product No.
Log in to see

Available images

Catalog No. ABIN6268202
$ 450.00
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
4 ABIN6268618 ELISA WB Rabbit IgG Log in to see Polyclonal 0
1 ABIN2286598 IHC ELISA WB Rabbit IgG N-Term, AA 16-45 Log in to see Polyclonal 0
1 ABIN2286599 ELISA WB Rabbit IgG Center Log in to see Polyclonal 0
1 ABIN1974481 IHC ELISA WB PE Rabbit IgG AA 9-37 Log in to see Polyclonal 0
1 ABIN1963446 IHC ELISA WB APC Rabbit IgG AA 9-37 Log in to see Polyclonal 0
1 ABIN1969893 IHC ELISA WB FITC Rabbit IgG AA 9-37 Log in to see Polyclonal 0
1 ABIN1972145 IHC ELISA WB HRP Rabbit IgG AA 9-37 Log in to see Polyclonal 0
1 ABIN1961070 IHC ELISA WB Alkaline Phosphatase (AP) Rabbit IgG AA 9-37 Log in to see Polyclonal 0
1 ABIN1966111 IHC ELISA WB Biotin Rabbit IgG AA 9-37 Log in to see Polyclonal 0
1 ABIN2589686 ELISA IHC WB Rabbit IgG AA 9-37 Log in to see Polyclonal 0
1 ABIN2286605 IHC ELISA WB HRP Rabbit IgG N-Term, AA 16-45 Log in to see Polyclonal 0
1 ABIN2286606 IHC ELISA WB PE Rabbit IgG N-Term, AA 16-45 Log in to see Polyclonal 0
1 ABIN2286602 IHC ELISA WB APC Rabbit IgG N-Term, AA 16-45 Log in to see Polyclonal 0
1 ABIN2286604 IHC ELISA WB FITC Rabbit IgG N-Term, AA 16-45 Log in to see Polyclonal 0
1 ABIN2286607 ELISA WB Chicken IgY AA 18-143 Log in to see Polyclonal 0
1 ABIN2286601 IHC ELISA WB Alkaline Phosphatase (AP) Rabbit IgG N-Term, AA 16-45 Log in to see Polyclonal 0
1 ABIN2286603 IHC ELISA WB Biotin Rabbit IgG N-Term, AA 16-45 Log in to see Polyclonal 0
1 ABIN5921360 ELISA WB Rabbit Log in to see Polyclonal 0

General

Antigen BRISC and BRCA1 A Complex Member 1 (BABAM1) Antibodies
Epitope pSer29
(11), (10), (7), (4), (3), (2), (2), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(36), (4), (3), (2), (2), (2), (1), (1)
Host Rabbit
(29), (4), (2), (1)
Clonality
Polyclonal
Conjugate Un-conjugated
(2), (2), (2), (2), (2), (2)
Application ELISA, Western Blotting (WB)
(34), (20), (18), (7), (4), (3), (1), (1)
Supplier Log in to see

Product details

Target Details Application Details Handling Images
Specificity Phospho-MERIT40 (Ser29) Antibody detects endogenous levels of MERIT40 only when phosphorylated at Ser29
Cross-Reactivity Human, Mouse (Murine), Rat (Rattus)
Purification The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Immunogen A synthesized peptide derived from human MERIT40 around the phosphorylation site of Ser29
Isotype IgG

Target Details

Product details Application Details Handling Images back to top
Antigen
Alternative Name MERIT40 (BABAM1 Antibody Abstract)
Background

Description: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:24075985, PubMed:26195665). In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1, deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985).

Gene: BABAM1

Molecular Weight 40kDa
Gene ID 29086
UniProt Q9NWV8
Pathways Positive Regulation of Response to DNA Damage Stimulus

Application Details

Product details Target Details Handling Images back to top
Application Notes WB 1:500-1:2000
Restrictions For Research Use only

Handling

Product details Target Details Application Details Images back to top
Format Liquid
Concentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20 °C.Stable for 12 months from date of receipt
Expiry Date 12 months

Images

Product details Target Details Application Details Handling back to top
Supplier Images
Western Blotting (WB) image for anti-BRISC and BRCA1 A Complex Member 1 (BABAM1) (pSer29) antibody (ABIN6268202) Western blot analysis of Phospho-MERIT40 (Ser29) in lysates of A-431?, using Phospho-...