anti-Guinea Pig BRE antibody for Western Blotting

Recommended BRE Antibody (supplied by: Log in to see )

Antigen
Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE) Antibodies
  • brcc4
  • brcc45
  • BRE
  • LOC100231620
  • BRCC4
  • BRCC45
  • 6030405P19Rik
  • AI429776
  • B830038C02Rik
  • im:7141046
  • zgc:110368
  • BRISC and BRCA1 A complex member 2
  • brain and reproductive organ-expressed (TNFRSF1A modulator)
  • BRISC and BRCA1 A complex member 2 L homeolog
  • babam2
  • BABAM2
  • Babam2
  • BRE
  • babam2.L
Epitope
C-Term
8
5
3
3
3
2
2
1
1
1
Reactivity
Cow (Bovine), Dog (Canine), Guinea Pig, Horse (Equine), Human, Mouse (Murine), Rabbit, Rat (Rattus), Zebrafish (Danio rerio)
68
51
41
1
Host
Rabbit
65
3
Clonality
Polyclonal
Conjugate
This BRE antibody is un-conjugated
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
53
25
24
20
20
13
13
5
3
2
1
1
1
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Supplier
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Available images

Catalog No. ABIN2789082
$ 289.00
Plus shipping costs $45.00

General

Antigen Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE) Antibodies
Epitope C-Term
(8), (5), (3), (3), (3), (2), (2), (1), (1), (1)
Reactivity Cow (Bovine), Dog (Canine), Guinea Pig, Horse (Equine), Human, Mouse (Murine), Rabbit, Rat (Rattus), Zebrafish (Danio rerio)
(68), (51), (41), (1)
Host Rabbit
(65), (3)
Clonality
Polyclonal
Conjugate This BRE antibody is un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunohistochemistry (IHC), Western Blotting (WB)
(53), (25), (24), (20), (20), (13), (13), (5), (3), (2), (1), (1), (1)
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Product Details anti-BRE Antibody

Target Details BRE Application Details Handling Images
Blocking Peptide Blocking peptide for this product available: ABIN973885
Sequence YHFTNSGQLY SQAQKNYPYS PRWDGNEMAK RAKAYFKTFV PQFQEAAFAN
Predicted Reactivity Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%
Characteristics This is a rabbit polyclonal antibody against BRE. It was validated on Western Blot.
Purification Affinity Purified
Plasmids, Primers & others

Target Details BRE

Product Details anti-BRE Antibody Application Details Handling Images back to top
Antigen
Alternative Name BRE (BRE Antibody Abstract)
Background BRE is a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. BRE probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. BRE may play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. BRE may also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway anf regulate TNF-alpha signaling through its interactions with TNFRSF1A, however these effects may be indirect.
Alias Symbols: BRCC4, BRCC45
Protein Interaction Partner: FAM175B, UBC, BABAM1, AKAP2, TFG, OPTN, HNRNPA2B1, SUMO2, PAXIP1, MDC1, BRCA1, GRB2, UBD, GFI1B, UIMC1, BRCC3, FAM175A, NCOA3, COPS5, SUMO1, TNFRSF1A, FAS, MMS19, UGGT2, TMX3, DHRS7B, FKBP8, TTC28, ATG2A, SLC25A13, LRPPRC, USP7, SSR3, SHMT2, RPN2, PHB, UB
Protein Size: 383
Molecular Weight 43 kDa
Gene ID 9577
NCBI Accession NM_199194, NP_954664
UniProt Q9NXR7
Pathways Positive Regulation of Response to DNA Damage Stimulus

Application Details

Product Details anti-BRE Antibody Target Details BRE Handling Images back to top
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 383 AA

Restrictions For Research Use only

Handling

Product Details anti-BRE Antibody Target Details BRE Application Details Images back to top
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Images

Product Details anti-BRE Antibody Target Details BRE Application Details Handling back to top
Supplier Images
Western Blotting (WB) image for anti-Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE) (C-Term) antibody (ABIN2789082) anti-Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE) (C-Term) antibody