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PPM1F Products

(Protein Phosphatase 1F (PP2C Domain Containing) (PPM1F))

Categories

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined. [provided by RefSeq, Jul 2008].

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Featured PPM1F Categories

PPM1F Antibodies

High quality antibodies with extensive validation data.

PPM1F Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended PPM1F Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, IF, IHC, WB
Validations
  • (4)
Cat. No. ABIN7165944
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, WB
Validations
  • (4)
Cat. No. ABIN564170
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application IP, ELISA, WB
Validations
  • (3)
Cat. No. ABIN523141
Quantity 100 μg
Datasheet Datasheet

Recommended PPM1F ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6232997
Quantity 96 tests
Datasheet Datasheet

Recommended PPM1F Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3125997
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1315912
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1315914
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our PPM1F products

Harvey, Banga, Ozer: "Regulation of the multifunctional Ca2+/calmodulin-dependent protein kinase II by the PP2C phosphatase PPM1F in fibroblasts." in: The Journal of biological chemistry, Vol. 279, Issue 23, pp. 24889-98, (2004) (PubMed).

Izmailova, Bertley, Huang, Makori, Miller, Young, Aldovini: "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages." in: Nature medicine, Vol. 9, Issue 2, pp. 191-7, (2003) (PubMed).

Koh, Tan, Manser, Lim: "The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family." in: Current biology : CB, Vol. 12, Issue 4, pp. 317-21, (2002) (PubMed).

Tan, Chan, Tan, Yu: "The Caenorhabditis elegans sex-determining protein FEM-2 and its human homologue, hFEM-2, are Ca2+/calmodulin-dependent protein kinase phosphatases that promote apoptosis." in: The Journal of biological chemistry, Vol. 276, Issue 47, pp. 44193-202, (2001) (PubMed).

Kitani, Ishida, Okuno, Takeuchi, Kameshita, Fujisawa: "Molecular cloning of Ca2+/calmodulin-dependent protein kinase phosphatase." in: Journal of biochemistry, Vol. 125, Issue 6, pp. 1022-8, (1999) (PubMed).

Synonyms and alternative names related to PPM1F

protein phosphatase, Mg2+/Mn2+ dependent 1F (PPM1F), protein phosphatase 1F (PP2C domain containing) (Ppm1f), protein phosphatase, Mg2+/Mn2+ dependent, 1F (Ppm1f), 1110021B16Rik, 4933427B07Rik, CAMKP, CaMKPase, FEM-2, hFEM-2, mKIAA0015, Popx2, POPX2

Protein level used designations for PPM1F

  • ca(2+)/calmodulin-dependent protein kinase phosphatase
  • caM-kinase phosphatase
  • calcium/calmodulin-dependent protein kinase phosphatase
  • partner of PIX2
  • protein phosphatase 1F
  • Ca(2+)/calmodulin-dependent protein kinase phosphatase
  • CaM-kinase phosphatase
  • PP2C phosphatase
  • partner of PIX 2
  • protein fem-2 homolog
  • protein phosphatase 1F (PP2C domain containing)
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