anti-Mouse (Murine) BRE antibody for Immunoprecipitation

Recommended BRE Antibody (supplied by: Log in to see )

Antigen
Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE) Antibodies
  • brcc4
  • brcc45
  • BRE
  • LOC100231620
  • BRCC4
  • BRCC45
  • 6030405P19Rik
  • AI429776
  • B830038C02Rik
  • im:7141046
  • zgc:110368
  • BRISC and BRCA1 A complex member 2
  • brain and reproductive organ-expressed (TNFRSF1A modulator)
  • BRISC and BRCA1 A complex member 2 L homeolog
  • babam2
  • BABAM2
  • Babam2
  • BRE
  • babam2.L
Epitope
Center
7
5
5
3
2
2
1
1
1
1
Reactivity
Human, Mouse (Murine)
65
49
41
2
2
2
2
2
2
1
1
1
1
1
1
Host
Rabbit
62
3
Clonality
Polyclonal
Conjugate
This BRE antibody is un-conjugated
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
51
24
24
19
16
13
9
3
3
2
1
1
1
Options
Supplier
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Supplier Product No.
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Available images

Catalog No. ABIN2856093
$ 466.18
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
6.8602448 ABIN442275 ICC IF IP WB Rabbit IgG Center Log in to see Polyclonal 0

General

Antigen Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE) Antibodies
Epitope Center
(7), (5), (5), (3), (2), (2), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine)
(65), (49), (41), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Host Rabbit
(62), (3)
Clonality
Polyclonal
Conjugate This BRE antibody is un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
(51), (24), (24), (19), (16), (13), (9), (3), (3), (2), (1), (1), (1)
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Product Details anti-BRE Antibody

Target Details BRE Application Details Handling Images
Cross-Reactivity Cow (Bovine)
Cross-Reactivity (Details) Bovine (100 %)
Characteristics Rabbit Polyclonal antibody to BRCC45 (brain and reproductive organ-expressed (TNFRSF1A modulator))
BRCC45 antibody
Purification Purified by antigen-affinity chromatography.
Immunogen Recombinant protein encompassing a sequence within the center region of human BRCC45. The exact sequence is proprietary.
Isotype IgG
Plasmids, Primers & others

Target Details BRE

Product Details anti-BRE Antibody Application Details Handling Images back to top
Antigen
Alternative Name BRCC45 (BRE Antibody Abstract)
Background Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between MERIT40/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF-alpha signaling through its interactions with TNFRSF1A, however these effects may be indirect.

Cellular Localization: Cytoplasm , Nucleus
Molecular Weight 44 kDa
Gene ID 9577
Pathways Positive Regulation of Response to DNA Damage Stimulus

Application Details

Product Details anti-BRE Antibody Target Details BRE Handling Images back to top
Application Notes Suggested dilution Reference ICC/IF 1:100-1:1000* Immunoprecipitation 1:100-1:500* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceICC/IF1:100-1:1000* Immunoprecipitation1:100-1:500* Western blot1:500-1:3000*
Comment

Positive Control: 293T , A431 , C8D30

Restrictions For Research Use only

Handling

Product Details anti-BRE Antibody Target Details BRE Application Details Images back to top
Format Liquid
Concentration 1 mg/mL
Buffer 0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Images

Product Details anti-BRE Antibody Target Details BRE Application Details Handling back to top
Supplier Images
Western Blotting (WB) image for anti-Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE) (Center) antibody (ABIN2856093) WB Image BRCC45 antibody detects BRE protein by Western blot analysis. A. 30 µg 293T ...
Immunoprecipitation (IP) image for anti-Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE) (Center) antibody (ABIN2856093) IP Image BRE antibody immunoprecipitates BRE protein in IP experiments. IP Sample: 10...
Western Blotting (WB) image for anti-Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE) (Center) antibody (ABIN2856093) WB Image BRCC45 antibody detects BRE protein by Western blot analysis. A. 30 ug C8D30...
Immunofluorescence (IF) image for anti-Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE) (Center) antibody (ABIN2856093) ICC/IF Image Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using BRE, a...