HNRNPD/AUF1 Protein (AA 18-355, partial) (GST tag)
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- Target See all HNRNPD/AUF1 (HNRNPD) Proteins
- HNRNPD/AUF1 (HNRNPD) (Heterogeneous Nuclear Ribonucleoprotein D (HNRNPD))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 18-355, partial
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This HNRNPD/AUF1 protein is labelled with GST tag.
- Application
- SDS-PAGE (SDS), ELISA
- Sequence
- AVGGSAGEQE GAMVAATQGA AAAAGSGAGT GGGTASGGTE GGSAESEGAK IDASKNEEDE GHSNSSPRHS EAATAQREEW KMFIGGLSWD TTKKDLKDYF SKFGEVVDCT LKLDPITGRS RGFGFVLFKE SESVDKVMDQ KEHKLNGKVI DPKRAKAMKT KEPVKKIFVG GLSPDTPEEK IREYFGGFGE VESIELPMDN KTNKRRGFCF ITFKEEEPVK KIMEKKYHNV GLSKCEIKVA MSKEQYQQQQ QWGSRGGFAG RARGRGGDQQ SGYGKVSRRG GHQNSYKPY
- Characteristics
- Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Ref.13 Ref.30
- Purity
- 90 %
- Top Product
- Discover our top product HNRNPD Protein
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- Comment
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Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS buffer, 20mM GSH
- Storage
- -20 °C
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Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, (2003) (PubMed).
: "The human HNRPD locus maps to 4q21 and encodes a highly conserved protein." in: Genomics, Vol. 49, Issue 3, pp. 378-84, (1998) (PubMed).
: "The UUAG-specific RNA binding protein, heterogeneous nuclear ribonucleoprotein D0. Common modular structure and binding properties of the 2xRBD-Gly family." in: The Journal of biological chemistry, Vol. 270, Issue 38, pp. 22167-75, (1995) (PubMed).
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Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, (2003) (PubMed).
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- Target
- HNRNPD/AUF1 (HNRNPD) (Heterogeneous Nuclear Ribonucleoprotein D (HNRNPD))
- Alternative Name
- Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD Products)
- Synonyms
- AUF1 Protein, AUF1A Protein, HNRPD Protein, P37 Protein, hnRNPD0 Protein, Auf1 Protein, Hnrnpd Protein, HNRNPD Protein, p37 Protein, auf1a Protein, hnrpd Protein, hnrnpd0 Protein, C230004L04 Protein, Hnrpd Protein, wu:fa28b06 Protein, zgc:162951 Protein, heterogeneous nuclear ribonucleoprotein D Protein, heterogeneous nuclear ribonucleoprotein D L homeolog Protein, HNRNPD Protein, Hnrnpd Protein, hnrnpd Protein, hnrnpd.L Protein
- Background
- Synonyms: AU-rich element RNA-binding protein 1
- Molecular Weight
- 58.6 kD
- UniProt
- Q14103
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