TNFRSF21 Protein (AA 42-350) (His tag)
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- Target See all TNFRSF21 Proteins
- TNFRSF21 (Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 42-350
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Origin
- Human
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Source
- Human Cells
- Purification tag / Conjugate
- This TNFRSF21 protein is labelled with His tag.
- Purpose
- Recombinant Human Death Receptor 6/DR6/TNFRSF21/CD358 (C-6His)
- Sequence
- QPEQKASNLI GTYRHVDRAT GQVLTCDKCP AGTYVSEHCT NTSLRVCSSC PVGTFTRHEN GIEKCHDCSQ PCPWPMIEKL PCAALTDREC TCPPGMFQSN ATCAPHTVCP VGWGVRKKGT ETEDVRCKQC ARGTFSDVPS SVMKCKAYTD CLSQNLVVIK PGTKETDNVC GTLPSFSSST SPSPGTAIFP RPEHMETHEV PSSTYVPKGM NSTESNSSAS VRPKVLSSIQ EGTVPDNTSS ARGKEDVNKT LPNLQVVNHQ QGPHHRHILK LLPSMEATGG EKSSTPIKGP KRGHPRQNLH KHFDINEHLV DHHHHHH
- Characteristics
- Recombinant Human Tumor Necrosis Factor Receptor Superfamily Member 21/TNFRSF21 is produced with our mammalian expression system in human cells. The target protein is expressed with sequence (Gln42-Leu350) of Human TNFRSF21 fused with a polyhistidine tag at the C-terminus.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Sterility
- 0.2 μm filtered
- Endotoxin Level
- Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
- Top Product
- Discover our top product TNFRSF21 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
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It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. - Buffer
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.
- Handling Advice
- Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
- Storage
- 4 °C/-20 °C/-80 °C
- Storage Comment
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Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months. - Expiry Date
- 3 months
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- Target
- TNFRSF21 (Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21))
- Alternative Name
- dr6 (TNFRSF21 Products)
- Synonyms
- TNFRSF21 Protein, tnfrsf21 Protein, MGC146356 Protein, BM-018 Protein, CD358 Protein, DR6 Protein, AA959878 Protein, R74815 Protein, TR7 Protein, dr6 Protein, im:6795346 Protein, wu:fa55e01 Protein, wu:fb02e11 Protein, wu:fc29a09 Protein, wu:fi27h08 Protein, TNF receptor superfamily member 21 Protein, tumor necrosis factor receptor superfamily member 21 Protein, tumor necrosis factor receptor superfamily, member 21 Protein, TNFRSF21 Protein, tnfrsf21 Protein, Tnfrsf21 Protein
- Sub Type
- Fusionprotein
- Background
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Tumor Necrosis Factor Receptor Superfamily Member 21 (TNFRSF21) is a type I transmembrane receptor that includes four extracellular cysteine-rich motifs and a cytoplasmic death domain. DR6 is highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. DR6 may activate NF-kappa-B and JNK to promote apoptosis and T-cell differentiation. In addition, DR6 binds with N-APP, which is released by the deprivation of Trophic-factor. It triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). DR6 is also expressed on the tumor cell lines and can be induced by TNF-alpha.
Alternative Names: Tumor Necrosis Factor Receptor Superfamily Member 21, Death Receptor 6, CD358, TNFRSF21, DR6 - Molecular Weight
- 34.62 kDa
- UniProt
- O75509
- Pathways
- Regulation of Lipid Metabolism by PPARalpha
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