FGF23 Protein (AA 1-251) (Fc Tag)
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- Target See all FGF23 Proteins
- FGF23 (Fibroblast Growth Factor 23 (FGF23))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 1-251
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This FGF23 protein is labelled with Fc Tag.
- Application
- SDS-PAGE (SDS)
- Cross-Reactivity
- Human
- Characteristics
- Signal peptide and human FGF-23 (aa 1-251) are fused at the C-terminus to the Fc portion of human IgG1.
- Purity
- >90 % (SDS-PAGE)
- Sterility
- 0.2 μm filtered
- Endotoxin Level
- <0.1EU/μg purified protein (LAL test, Lonza).
- Top Product
- Discover our top product FGF23 Protein
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Fibroblast Growth Factor 23 (FGF23) (AA 25-251) (Active) protein (His tag)
FGF23 Origin: Mouse Host: Escherichia coli (E. coli) > 90 % AcA, CC Active
Fibroblast Growth Factor 23 (FGF23) (AA 25-251) protein (His tag)FGF23 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Fibroblast Growth Factor 23 (FGF23) (AA 1-251) protein (GST tag)FGF23 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Fibroblast Growth Factor 23 (FGF23) (AA 25-251), (full length) protein (His tag)FGF23 Origin: Rat Host: Yeast Recombinant > 90 % ELISA
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
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Activates ERK and FRS2alpha phosphorylation in Klotho expressing cells.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- 0.2μm-filtered solution in PBS.
- Storage
- 4 °C,-20 °C
- Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Working aliquots are stable for up to 3 months when stored at -20°C. - Expiry Date
- 3 months
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- Target
- FGF23 (Fibroblast Growth Factor 23 (FGF23))
- Alternative Name
- FGF-23 (FGF23 Products)
- Synonyms
- FGF23 Protein, ADHR Protein, FGFN Protein, HPDR2 Protein, HYPF Protein, PHPTC Protein, fibroblast growth factor 23 Protein, fgf23 Protein, FGF23 Protein, Fgf23 Protein
- Background
- FGF-23 (Fibroblast growth factor 23) is a regulator of phosphate homeostasis. It upregulates EGR1 expression in the presence of KLBy. Acts directly on the parathyroid to decrease PTH secretion. Regulates the vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. Defects in FGF-23 are the cause of autosomal dominant hypophosphataemic rickets (ADHR) and of hyperphosphatemic familial tumoral calcinosis (HFTC).
- Molecular Weight
- ~60kDa (SDS-PAGE, full-length) FGF23 is cleaved between arg179 and ser 180 (~40kDa).
- UniProt
- Q9GZV9
- Pathways
- RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Negative Regulation of Hormone Secretion
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