CD40 Protein (CD40) (AA 21-193) (Fc Tag)
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- Target See all CD40 Proteins
- CD40
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 21-193
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Origin
- Human, Mouse
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This CD40 protein is labelled with Fc Tag.
- Application
- SDS-PAGE (SDS)
- Specificity
- Binds human and mouse CD40L.
- Cross-Reactivity
- Human, Mouse (Murine)
- Characteristics
- The Fc portion of human IgG1 is fused to the C-terminus of human CD40 (aa 21-193).
- Purity
- >95 % (SDS-PAGE)
- Endotoxin Level
- <0.01EU/μg purified protein (LAL test, Lonza).
- Top Product
- Discover our top product CD40 Protein
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
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Blocks the binding of CD40L to CD40.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstitute with 50 μL sterile water. Further dilutions should be made with medium containing 5 % fetal calf serum or a carrier protein.
- Concentration
- Lot specific
- Buffer
- Lyophilized. Contains PBS.
- Storage
- 4 °C,-20 °C
- Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C. - Expiry Date
- 6 months
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- Target
- CD40
- Alternative Name
- CD40 (CD40 Products)
- Synonyms
- Bp50 Protein, CDW40 Protein, TNFRSF5 Protein, p50 Protein, AI326936 Protein, GP39 Protein, HIGM1 Protein, IGM Protein, IMD3 Protein, T-BAM Protein, TRAP Protein, Tnfrsf5 Protein, TNFSF5 Protein, CD40 molecule Protein, CD40 antigen Protein, CD40 Protein, Cd40 Protein
- Background
- CD40 belongs to the TNF-receptor superfamily and is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development and germinal center formation. The interaction of CD40-CD40L is necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells, including non-Hodgkin's and Hodgkin's lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary.
- Molecular Weight
- ~54kDa (SDS-PAGE)
- UniProt
- P25942
- Pathways
- NF-kappaB Signaling, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
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