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IGF-like family receptor 1 (IGFLR1) (AA 23-154) protein (Fc Tag)

IGFLR1 Origin: Human Host: HEK-293 Cells Recombinant >95 % (SDS-PAGE) SDS
Catalog No. ABIN1344141
  • Target See all IGF-like family receptor 1 (IGFLR1) Proteins
    IGF-like family receptor 1 (IGFLR1)
    Protein Type
    Recombinant
    Protein Characteristics
    AA 23-154
    Origin
    • 3
    • 1
    Human
    Source
    • 2
    • 1
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    Fc Tag
    Application
    SDS-PAGE (SDS)
    Specificity
    Binds to its ligand IGFL3 (human) in the subnanomolar range (< 1 ng /mL).
    Cross-Reactivity
    Human
    Characteristics
    Human IGFLR1 (aa 23-154) is fused at the C-terminus to the Fc portion of human IgG1.
    Purity
    >95 % (SDS-PAGE)
    Endotoxin Level
    <0.05EU/μg purified protein (LAL test, Lonza).
    Top Product
    Discover our top product IGFLR1 Protein
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Reconstitute with 50 μL sterile water.
    Concentration
    Lot specific
    Buffer
    Lyophilized. Contains PBS.
    Storage
    4 °C,-20 °C
    Storage Comment
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 6 months after receipt when stored at -20°C.
    Expiry Date
    6 months
  • Target
    IGF-like family receptor 1 (IGFLR1)
    Alternative Name
    IGFLR1 (IGFLR1 Products)
    Background
    Insulin-growth factor-like gene family is a new family of proteins consisting of four proteins in humans (IGFL1 to 4) and one in mice (mIGFL). mIGFL is expressed in normal skin in mice and further upregulated during inflammation responses in skin or after skin wounding. In human only IGFL1 expression is increased in psoriatic skin samples. mIGFL and human IGFL1 and 3 interact with specificity and high affinity to a novel receptor named IGF-like family receptor 1 (formerly TMEM-149). Analysis of the amino acid sequence of IGFLR1 indicated that this receptor is likely a novel member of the TNF-R family. IGFLR1 is expressed most abundantly on mouse T cells, suggesting that mIGFL and IGFL1 produced in the skin may potentially exert regulatory functions on T cell responses.
    Molecular Weight
    ~50kDa (SDS-PAGE)
    UniProt
    Q9H665
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