CD72 Protein (AA 117-226) (His tag,TRX tag)

Catalog No. ABIN1691965

Product Details

Target: CD72 (CD72 Molecule (CD72))

Protein Type: Recombinant

Protein Characteristics: AA 117-226

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This CD72 protein is labelled with His tag,TRX tag.

Purpose: Recombinant Human B-Cell Differentiation Antigen CD72/Lyb-2 (N-Trx, 6His)

Sequence: MSDKIIHLTD DSFDTDVLKA DGAILVDFWA EWCGPCKMIA PILDEIADEY QGKLTVAKLN IDQNPGTAPK YGIRGIPTLL LFKNGEVAAT KVGALSKGQL KEFLDANLAG SGSGHMHHHH HHSSGLVPRG SGMKETAAAK FERQHMDSPD LGTDDDDKAM ADIGSMRYLQ VSQQLQQTNR VLEVTNSSLR QQLRLKITQL GQSAEDLQGS RRELAQSQEA LQVEQRAHQA AEGQLQACQA DRQKTKETLQ SEEQQRRALE QKLSNMENRL KPFFTC

Characteristics: Recombinant Human B-Cell Differentiation Antigen CD72/CD72 is produced with our E. coli expression system. The target protein is expressed with sequence (Arg117-Cys226) of Human CD72.

Purity: > 95 % as determined by reducing SDS-PAGE.

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.

Handling Advice: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Storage: 4 °C/-20 °C/-80 °C

Storage Comment: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 3 months

Target Details

Target: CD72 (CD72 Molecule (CD72))

Alternative Name: CD72 (CD72 Products)

Synonyms: CD72c Protein, Ly-19 Protein, Ly-32 Protein, Ly-m19 Protein, Lyb-2 Protein, CD72b Protein, LYB2 Protein, CD72 antigen Protein, CD72 molecule Protein, Cd72 Protein, CD72 Protein

Background: B-Cell Differentiation Antigen CD72 (CD72) is a single-pass type II membrane protein. CD72 exists as a disulfide-linked homodimer and contains one C-type lectin domain. CD72 is expressed on B lineage cells, NK cells, monocytes, dendritic cells, and mast cells. CD72 is a ligand for CD5. CD72 associates with CD5, interacts with PTPN6/SHP-1 and plays a role in B-cell proliferation and differentiation. CD72 associates with CD79A in the B cell antigen receptor (BCR) complex following antigen stimulation and dampens BCR signaling through interactions with the phosphatase SHP-1.
Alternative Names: B-Cell Differentiation Antigen CD72, Lyb-2, CD72

Molecular Weight: 30.6 kDa

UniProt: P21854

Pathways: BCR Signaling