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IL12 Protein (AA 23-215, AA 23-335)

Recombinant IL12 protein expressed in CHO Cells.
Catalog No. ABIN2018058

Quick Overview for IL12 Protein (AA 23-215, AA 23-335) (ABIN2018058)

Target

See all IL12 Proteins
IL12 (Interleukin 12 (IL12))

Protein Type

Recombinant

Biological Activity

Active

Origin

  • 22
  • 14
  • 4
  • 1
Mouse

Source

  • 17
  • 6
  • 4
  • 3
  • 3
  • 2
  • 2
CHO Cells

Purity

> 95 % as analyzed by SDS-PAGE.
  • Protein Characteristics

    AA 23-215, AA 23-335

    Characteristics

    ED50 < 0.15 ng/mL, measured in a cell proliferation assay using 2D6 cells.
    AA 23-215 (p35) and AA 23-335 (p40), expressed with C-terminal 6xHis.

    Endotoxin Level

    < 0.2 EU/μg, determined by LAL method.
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  • Restrictions

    For Research Use only
  • Format

    Lyophilized

    Reconstitution

    Reconstituted in ddH2O or PBS at 100 μg/mL.

    Buffer

    Lyophilized after extensive dialysis against PBS.

    Storage

    -80 °C

    Storage Comment

    Lyophilized recombinant murineInterleukin-12 (IL-12), remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, murine Interleukin-12 (IL-12), His should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.

    Expiry Date

    6 months
  • Target

    IL12 (Interleukin 12 (IL12))

    Alternative Name

    Interleukin-12 (IL-12)

    Background

    Interleukin-12 (IL-12), also known as NKSF, TCMF, CLMF and TSF, is a heterodimeric cytokine composed of p35 and p40 subunits. It is produced by monocytes, macrophages, B cells and dendritic cells in response to bacterial lipopolysaccharides and intracellular pathogens. IL-12 signals throughtheIL-12 receptor complex, which is comprised of IL-12 Rbeta1 and IL-12 Rbeta2. IL-12 induces the proliferation and activation of hematopoietic stem cells, natural killer cells and T- cells. It is indispensible during the development of Th1 cells, leading to the production of IFN-gamma and IL-2.
    Synonyms: NKSF, TCMF, CLMF, TSF

    Molecular Weight

    27-29 kDa (p35) and 45-50 kDa (p40), observed by reducing SDS-PAGE.

    UniProt

    P43431, P43432

    Pathways

    JAK-STAT Signaling, TLR Signaling, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation, Cancer Immune Checkpoints, Inflammasome
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