CNTN2 Protein (AA 31-1012) (His tag)
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- Target See all CNTN2 Proteins
- CNTN2 (Contactin 2 (Axonal) (CNTN2))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 31-1012
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This CNTN2 protein is labelled with His tag.
- Sequence
- AA 31-1012
- Characteristics
- This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 109 kDa. The protein migrates as 140 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Purity
- >95 % as determined by SDS-PAGE.
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product CNTN2 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Handling Advice
- Please avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- No activity loss was observed after storage at: 4-8°C for 1 year in lyophilized state 4-8°C for 1 month under sterile conditions after reconstitution -20°C to -70°C for 3 months under sterile conditions after reconstitution
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- Target
- CNTN2 (Contactin 2 (Axonal) (CNTN2))
- Alternative Name
- Contactin-2 (CNTN2 Products)
- Synonyms
- tag1 Protein, si:dz37k09.2 Protein, CNTN2 Protein, D130012K04Rik Protein, TAG-1 Protein, Tax Protein, AXT Protein, TAX Protein, TAX1 Protein, AXONIN-1 Protein, TAG-564 Protein, TAG1 Protein, contactin 2 Protein, contactin 2 (axonal) Protein, cntn2 Protein, CNTN2 Protein, Cntn2 Protein
- Background
- Contactin-2 is also known as CNTN2, TAX1 (transiently-expressed axonal glycoprotein), TAG1 (transient axonal glycoprotein), and axonin-1, and is a member of the immunoglobulin superfamily. CNTN2 consists of six Ig-like domains and four fibronectin type III domains, and is anchored to the membrane by glycosylphosphatidylinositol (GPI), whereas the soluble form can be released by a GPI-specific phospholipase. As a neural cell adhesion molecule expressed by a subset of neuronal populations in the developing CNS and PNS, CNTN2 mediates cell-cell interactions either via homophilic, or heterophilic contacts with various adhesion molecules including NgCAM, NrCAM, NCAM and neurocan. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. It may also be involved in glial tumorigenesis and may provide a potential target for therapeutic intervention.
- Molecular Weight
- 108.3 kDa
- NCBI Accession
- NP_005067
- Pathways
- Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of Cell Size
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