Growth Hormone Receptor Protein (GHR) (AA 27-264) (Fc Tag)
Quick Overview for Growth Hormone Receptor Protein (GHR) (AA 27-264) (Fc Tag) (ABIN2181157)
Target
See all Growth Hormone Receptor (GHR) ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Protein Characteristics
- AA 27-264
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Purification tag / Conjugate
- This Growth Hormone Receptor protein is labelled with Fc Tag.
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Sequence
- AA 27-264
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Characteristics
- This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 54.3 kDa. As a result of glycosylation, the protein migrates as 66-85 kDa under reducing (R) condition, and 135-160 kDa under non-reducing (NR) condition (SDS-PAGE).
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Sterility
- 0.22 μm filtered
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Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
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Growth Hormone Receptor (GHR) (AA 27-264) (Active) protein (His tag)
GHR Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Growth Hormone Receptor (GHR) (AA 27-264) (Active) protein (His tag)GHR Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Growth Hormone Receptor (GHR) protein (Fc Tag)GHR Origin: Mouse Host: Human Cells Recombinant > 95 % as determined by SDS-PAGE
Growth Hormone Receptor (GHR) (AA 27-264) (Active) protein (His-Fc tag)GHR Origin: Human Host: Mammalian Cells Recombinant >90 % as determined by SDS-PAGE. SDS, WB, ELISA, Imm, AcA Active
Growth Hormone Receptor (GHR) (AA 27-264) protein (Fc Tag)GHR Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
Growth Hormone Receptor (GHR) (Active) protein (His tag)GHR Origin: Rat Host: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
Growth Hormone Receptor (GHR) (Active) protein (His tag,Fc Tag)GHR Origin: Mouse Host: HEK-293 Cells Recombinant > 85 % as determined by SDS-PAGE Active
Growth Hormone Receptor (GHR) (Active) protein (Fc Tag)GHR Origin: Rat Host: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
Growth Hormone Receptor (GHR) (Active) protein (His tag)GHR Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
Growth Hormone Receptor (GHR) (AA 19-264) (Active) protein (Fc Tag)GHR Origin: Rhesus Monkey Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- PBS, pH 7.4
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Handling Advice
- Please avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
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- Growth Hormone Receptor (GHR)
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Alternative Name
- GHR
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Background
- Growth hormone receptor (GHR) is also known as somatotropin receptor, growth hormone-binding protein (GHBR), which belongs to the type I cytokine receptor family or Type 1 subfamily. GHR contains one fibronectin type-III domain. GHR / GHBR is expressed in various tissues with high expression in liver and skeletal muscle. The soluble form (GHBP) is produced by phorbol ester-promoted proteolytic cleavage at the cell surface (shedding) by ADAM17/TACE. GHR is receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.
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Molecular Weight
- 54.3 kDa
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UniProt
- P10912
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Pathways
- NF-kappaB Signaling, JAK-STAT Signaling, Response to Growth Hormone Stimulus
Target
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