IL18BP Protein (AA 31-194) (His tag)
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- Target See all IL18BP Proteins
- IL18BP (Interleukin 18 Binding Protein (IL18BP))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 31-194
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This IL18BP protein is labelled with His tag.
- Sequence
- AA 31-194
- Characteristics
- This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 18.5 kDa. The protein migrates as 28-48 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Purity
- >90 % as determined by SDS-PAGE.
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product IL18BP Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Handling Advice
- Please avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
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- Target
- IL18BP (Interleukin 18 Binding Protein (IL18BP))
- Alternative Name
- IL-18BP (IL18BP Products)
- Synonyms
- IL18BP Protein, IL-18BP Protein, Igifbp Protein, MC54L Protein, IL18BPa Protein, interleukin 18 binding protein Protein, IL18BP Protein, Il18bp Protein
- Background
- Interleukin-18-binding protein (IL18BP) is also known as Tadekinig-alfa, IL18BPa, which functions as an IL18 inhibitor. IL18BP is a secreted protein which contains one Ig-like C2-type (immunoglobulin-like) domain. IL18BP does not have a transmembrane domain and hence is not anchored to the cell membrane. IL18BP is strongly expressed in heart, lung, placenta and spleen. Isoform A of IL18BP binds to IL-18 and inhibits its activity. IL18BP also functions as an inhibitor of the early TH1 cytokine response. IL18BP suppresses the production of IFN-gamma resulting in reduced T-helper type 1 immune responses.
- Molecular Weight
- 18.5 kDa
- NCBI Accession
- NP_001138529
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