ACVR2B Protein (His tag)

Catalog No. ABIN2566269

Product Details

Target: ACVR2B (Activin A Receptor, Type IIB (ACVR2B))

Protein Type: Recombinant

Biological Activity: Active

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This ACVR2B protein is labelled with His tag.

Application: Western Blotting (WB)

Characteristics:

Measured by its ability to inhibit Activin Ainduced hemoglobin expression in K562 human chronic myelogenous leukemia cells. Approximately 0. 2-0. 5 μg/mL of recombinant human ActivinR-IIB will inhibit 50 % of the biological response due to 3 ng/mL of rhActivin A.

Fusion tag: C-His Tag

Purity: >97 % as determined by SDS-PAGE.

Application Details

Application Notes: This recombinant protein can be used for WB. For research use only.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: PBS, pH 7.4

Storage: -80 °C,-20 °C

Storage Comment: Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.

Target Details

Target: ACVR2B (Activin A Receptor, Type IIB (ACVR2B))

Alternative Name: ACVR2B (ACVR2B Products)

Synonyms: ACVR2B Protein, XAR1 Protein, actr-iib Protein, actriib Protein, ACTRIIB Protein, ActR-IIB Protein, HTX4 Protein, ActRIIB Protein, actr2b Protein, actrIIb Protein, wu:fj97d11 Protein, activin A receptor type 2B Protein, activin A receptor type 2B L homeolog Protein, activin A receptor type 2Ba Protein, activin receptor IIB Protein, ACVR2B Protein, acvr2b Protein, acvr2b.L Protein, Acvr2b Protein, acvr2ba Protein

Background: Activin receptor type-2B (ACVR2B) is also known as ActR-IIB and MGC116908, ACVR2B is an activin type 2 receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. Defects in ACVR2B are the cause of visceral heterotaxy autosomal type 4 (HTX4).

Molecular Weight: 14.5 kDa

Gene ID: 93

NCBI Accession: NP_001097

UniProt: Q13705

Pathways: Hormone Transport, Cancer Immune Checkpoints