Osteoactivin Protein (GPNMB) (His tag)
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- Target See all Osteoactivin (GPNMB) Proteins
- Osteoactivin (GPNMB)
- Protein Type
- Recombinant
- Biological Activity
- Active
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This Osteoactivin protein is labelled with His tag.
- Application
- Western Blotting (WB)
- Characteristics
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Measured by the ability of the immobilized protein to induce pro-MMP-9 secretion by NHLF human normal lung fibroblasts. The ED50 for this effect is typically 4 - 16 μg/mL.
- Purity
- >95 % as determined by SDS-PAGE.
- Top Product
- Discover our top product GPNMB Protein
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Osteoactivin (GPNMB) (AA 23-486) protein (His tag)
GPNMB Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Osteoactivin (GPNMB) (AA 23-502) protein (His tag)GPNMB Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Osteoactivin (GPNMB) (AA 23-496) protein (His tag)GPNMB Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
Osteoactivin (GPNMB) (AA 1-572) protein (GST tag)GPNMB Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Osteoactivin (GPNMB) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)GPNMB Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Application Notes
- This recombinant protein can be used for WB. For research use only.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Storage
- -80 °C,-20 °C
- Storage Comment
- Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
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- Target
- Osteoactivin (GPNMB)
- Alternative Name
- Osteoactivin (GPNMB Products)
- Background
- Transmembrane glycoprotein NMB (GPNMB) is also known as Transmembrane glycoprotein HGFIN, DC-HIL and Osteoactivin (OA), which belongs to the PMEL/NMB family. GPNMB contains one PKD domain. GPNMB is a transmembrane glycoprotein that is up-regulated in various cancer cells, including in glioblastoma multiforme and is expressed in many melanoma cells, as well as in tissue macrophages. GPNMB protein acts as a downstream mediator of BMP-2 effects on osteoblast differentiation and function. GPNMB participates in bone mineralization, and functions as a negative regulator of inflammation in macrophages.
- Molecular Weight
- 52.9 kDa
- Gene ID
- 10457
- UniProt
- Q14956
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