BAG4 Protein (Myc-DYKDDDDK Tag)
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- Target See all BAG4 Proteins
- BAG4 (BCL2-Associated Athanogene 4 (BAG4))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This BAG4 protein is labelled with Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
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- Recombinant human BAG4 protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Purity
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product BAG4 Protein
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- Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Comment
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Target
- BAG4 (BCL2-Associated Athanogene 4 (BAG4))
- Alternative Name
- Bag4 (BAG4 Products)
- Synonyms
- BAG-4 Protein, SODD Protein, BAG4 Protein, fd20a04 Protein, wu:fd20a04 Protein, si:dkey-220o5.3 Protein, 2410112I15Rik Protein, ATBAG4 Protein, BCL-2-associated athanogene 4 Protein, BCL2 associated athanogene 4 Protein, BCL2-associated athanogene 4 Protein, BCL-2-associated athanogene 4 Protein, BAG4 Protein, Bag4 Protein, bag4 Protein
- Background
- The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
- Molecular Weight
- 49.4 kDa
- NCBI Accession
- NP_004865
- Pathways
- Regulation of Actin Filament Polymerization
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