LIN7C Protein (Myc-DYKDDDDK Tag)

Catalog No. ABIN2724765

Product Details

Target: LIN7C (Lin-7 Homolog C (LIN7C))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This LIN7C protein is labelled with Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human LIN7C protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: LIN7C (Lin-7 Homolog C (LIN7C))

Alternative Name: Lin7c (LIN7C Products)

Synonyms: LIN7C Protein, fb75b09 Protein, wu:fb75b09 Protein, zgc:101881 Protein, LIN-7-C Protein, LIN-7C Protein, MALS-3 Protein, MALS3 Protein, VELI3 Protein, 9130007B12Rik Protein, AI303698 Protein, AU019331 Protein, AW125731 Protein, D2Ertd520e Protein, Veli3 Protein, lin-7 homolog C, crumbs cell polarity complex component Protein, lin-7 homolog C L homeolog Protein, lin-7 homolog C (C. elegans) Protein, LIN7C Protein, lin7c.L Protein, lin7c Protein, Lin7c Protein

Background: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. [UniProtKB/Swiss-Prot Function]

Molecular Weight: 21.7 kDa

NCBI Accession: NP_060832

Pathways: Synaptic Membrane