MPZ Protein (Myc-DYKDDDDK Tag)

Catalog No. ABIN2726305

Product Details

Target: MPZ (Myelin Protein Zero (MPZ))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This MPZ protein is labelled with Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human MPZ protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: MPZ (Myelin Protein Zero (MPZ))

Alternative Name: Mpz (MPZ Products)

Synonyms: CHM Protein, CMT1 Protein, CMT1B Protein, CMT2I Protein, CMT2J Protein, CMT4E Protein, CMTDI3 Protein, CMTDID Protein, DSS Protein, HMSNIB Protein, MPP Protein, P0 Protein, Mpp Protein, P-zero Protein, p0 Protein, sc:d0186 Protein, wu:fc04b11 Protein, wu:fi30g06 Protein, zgc:103775 Protein, myelin protein zero Protein, myelin protein zero S homeolog Protein, MPZ Protein, Mpz Protein, mpz Protein, mpz.S Protein

Background: This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in this gene are associated with autosomal dominant form of Charcot-Marie-Tooth disease type 1 (CMT1B) and other polyneuropathies, such as Dejerine-Sottas syndrome (DSS) and congenital hypomyelinating neuropathy (CHN). A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism.

Molecular Weight: 28.4 kDa

NCBI Accession: NP_000521