MPZ Protein (Myc-DYKDDDDK Tag)
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- Target See all MPZ Proteins
- MPZ (Myelin Protein Zero (MPZ))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This MPZ protein is labelled with Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
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- Recombinant human MPZ protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Purity
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product MPZ Protein
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- Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Comment
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Target
- MPZ (Myelin Protein Zero (MPZ))
- Alternative Name
- Mpz (MPZ Products)
- Synonyms
- CHM Protein, CMT1 Protein, CMT1B Protein, CMT2I Protein, CMT2J Protein, CMT4E Protein, CMTDI3 Protein, CMTDID Protein, DSS Protein, HMSNIB Protein, MPP Protein, P0 Protein, Mpp Protein, P-zero Protein, p0 Protein, sc:d0186 Protein, wu:fc04b11 Protein, wu:fi30g06 Protein, zgc:103775 Protein, myelin protein zero Protein, myelin protein zero S homeolog Protein, MPZ Protein, Mpz Protein, mpz Protein, mpz.S Protein
- Background
- This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in this gene are associated with autosomal dominant form of Charcot-Marie-Tooth disease type 1 (CMT1B) and other polyneuropathies, such as Dejerine-Sottas syndrome (DSS) and congenital hypomyelinating neuropathy (CHN). A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism.
- Molecular Weight
- 28.4 kDa
- NCBI Accession
- NP_000521
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